{"id":"W2171149904","doi":"10.1002/jlcr.1917","title":"[<sup>11</sup>C]Methyl‐losartan as a potential ligand for PET imaging angiotensin II AT<sub>1</sub> receptors","year":2011,"lang":"en","type":"article","venue":"Journal of Labelled Compounds and Radiopharmaceuticals","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Losartan; Chemistry; Tetrazole; Radioligand; Angiotensin II; Angiotensin II receptor type 1; Angiotensin receptor; Receptor; Renin–angiotensin system; Ligand (biochemistry); Pharmacology; Blood pressure; Internal medicine; Stereochemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000300623,0.0002409563,0.000234436,0.0001170114,0.0001220314,0.0002913087,0.0003073086,0.0002865297,0.001239564],"category_scores_gemma":[0.0001956499,0.0001610404,0.00008659464,0.000121056,0.0002379368,0.0002629837,0.0001297547,0.0003701003,0.0005439179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003107888,"about_ca_system_score_gemma":0.000234384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006881527,"about_ca_topic_score_gemma":0.001531418,"domain_scores_codex":[0.999912,0.00003770935,0.000003200465,0.00001273547,0.00001584712,0.00001844159],"domain_scores_gemma":[0.9999366,0.00001764045,0.00001342039,0.000005828916,0.00001101239,0.00001545864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002800933,0.00001391936,0.0001111381,0.00004618084,0.000005102088,0.0001550305,0.00001778439,0.0003723335,0.99489,0.0003892139,0.0001229128,0.003596326],"study_design_scores_gemma":[0.00004090347,0.000546547,0.0009780547,0.00001396798,0.0000312757,0.0008990633,0.00002888321,0.002340201,0.986096,0.000156624,0.00885217,0.0000163329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9230229,0.01357055,0.05173068,0.0006897536,0.00009490243,0.0001325355,0.0003812668,0.0002726022,0.010105],"genre_scores_gemma":[0.9477208,0.004889032,0.03784451,0.0001909383,0.000060333,0.00006936985,0.0005012493,0.00006995234,0.00865379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239564,"threshold_uncertainty_score":0.004146755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777777822141067,"score_gpt":0.2686178055258964,"score_spread":0.2508400273044857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}