{"id":"W2171172082","doi":"10.1126/science.aab2116","title":"Distinct routes of lineage development reshape the human blood hierarchy across ontogeny","year":2015,"lang":"en","type":"article","venue":"Science","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":753,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science; Terry Fox Foundation; Canadian Cancer Society; Wellcome; Ontario Genomics Institute; Aplastic Anemia and Myelodysplasia Association of Canada; Ontario Institute for Cancer Research; Hospital for Sick Children; Wellcome Trust","keywords":"Progenitor cell; Biology; Haematopoiesis; Lineage (genetic); Stem cell; Multipotent Stem Cell; Progenitor; Cell biology; Immunology; Myeloid; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002760781,0.0001190547,0.0001634239,0.0007752011,0.0003392382,0.0009609556,0.000181608,0.0002079567,0.001239342],"category_scores_gemma":[0.0003905875,0.000144872,0.0001071442,0.0004174186,0.0005878578,0.0004783276,0.0004681165,0.0006120962,0.0004294563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003239074,"about_ca_system_score_gemma":0.000564813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001108902,"about_ca_topic_score_gemma":0.001781646,"domain_scores_codex":[0.9998364,0.00003483738,0.00001018453,0.00004888261,0.00004215126,0.00002749447],"domain_scores_gemma":[0.9998137,0.00004089959,0.00003635423,0.00002943609,0.00004221145,0.00003737021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000482704,0.00004393875,0.03223342,0.0001747794,0.00002331854,0.0004777256,0.002052961,0.0006680212,0.741619,0.04242799,0.001447293,0.1783488],"study_design_scores_gemma":[0.00006549961,0.0008672912,0.4133327,0.0003115733,0.0001095933,0.006524963,0.001884655,0.005398313,0.3585353,0.03261657,0.1802565,0.00009705598],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8871273,0.01238016,0.06806078,0.001038496,0.00005352917,0.00008604229,0.000883273,0.0004448582,0.02992544],"genre_scores_gemma":[0.9580659,0.006691784,0.02677998,0.0004643911,0.00003737946,0.00005238514,0.0005170918,0.00008870331,0.007302537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239342,"threshold_uncertainty_score":0.00414598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06226375833916309,"score_gpt":0.3473729046581248,"score_spread":0.2851091463189617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}