{"id":"W2171172082","doi":"10.1126/science.aab2116","title":"Distinct routes of lineage development reshape the human blood hierarchy across ontogeny","year":2015,"lang":"en","type":"article","venue":"Science","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":753,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Ontario Ministry of Research, Innovation and Science; Terry Fox Foundation; Canadian Cancer Society; Wellcome; Ontario Genomics Institute; Aplastic Anemia and Myelodysplasia Association of Canada; Ontario Institute for Cancer Research; Hospital for Sick Children; Wellcome Trust","keywords":"Progenitor cell; Biology; Haematopoiesis; Lineage (genetic); Stem cell; Multipotent Stem Cell; Progenitor; Cell biology; Immunology; Myeloid; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001501359,0.00007544147,0.0001272133,0.00004052094,0.0002061644,0.00002470634,0.0002853407,0.00002427789,0.00002167772],"category_scores_gemma":[0.0001971709,0.00004682831,0.00002318017,0.0003994575,0.000615926,0.00007681928,0.00005570133,0.00008073643,0.0000251669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004109384,"about_ca_system_score_gemma":0.0004500305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002827681,"about_ca_topic_score_gemma":0.0000510012,"domain_scores_codex":[0.9986069,0.00002114871,0.0002494347,0.0002056688,0.000669821,0.0002470254],"domain_scores_gemma":[0.9992422,0.00006070067,0.0000698804,0.0002876932,0.0001914169,0.0001481496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009329831,0.0005017676,0.4202134,0.0003698038,0.00005530557,0.0001006284,0.08396103,0.000009172414,0.487102,0.002185625,0.0002224701,0.005185463],"study_design_scores_gemma":[0.001072832,0.0001483654,0.4100441,0.0001706153,0.00003581432,0.00008212619,0.00116606,0.00008498608,0.584798,0.0001302711,0.00216233,0.0001045029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927009,0.00009520557,0.0003469021,0.0001521835,0.00009135242,0.0002060127,0.000004378804,0.00002425169,0.006378863],"genre_scores_gemma":[0.9957959,0.000002066111,0.003075617,0.00007600302,0.00003778653,0.000009262359,0.000005278273,0.000005585991,0.0009924796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09769597,"threshold_uncertainty_score":0.2269405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06226375833916309,"score_gpt":0.3473729046581248,"score_spread":0.2851091463189617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}