{"id":"W2171258357","doi":"10.1351/pac200476071579","title":"Minimalist proteins: Design of new molecular recognition scaffolds","year":2004,"lang":"en","type":"article","venue":"Pure and Applied Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; DNA; Footprinting; Zipper; Leucine zipper; bZIP domain; DNA-binding protein; Scaffold protein; Alanine; Biophysics; Biochemistry; Transcription factor; Amino acid; Gene; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009862376,0.0001589741,0.0001495066,0.00001088343,0.00003891363,0.00001636571,0.0001172796,0.0002151263,0.00003122533],"category_scores_gemma":[0.0000189474,0.0001586498,0.00004978877,0.00005180316,0.00005280667,0.000002306554,0.00004710082,0.00003821908,0.000004704765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006562542,"about_ca_system_score_gemma":0.0000922729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006237402,"about_ca_topic_score_gemma":4.500916e-7,"domain_scores_codex":[0.9992349,0.000008581433,0.000171843,0.0003051333,0.0001113362,0.000168207],"domain_scores_gemma":[0.9995523,0.000004082789,0.00009207925,0.000223084,0.00002871453,0.00009970713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001055104,0.00003910245,0.000002674172,0.00007389006,0.00003171932,0.00000219409,0.00002055792,0.00003912547,0.9915225,0.0001037848,0.0001161565,0.007942822],"study_design_scores_gemma":[0.0006169326,0.00006998357,0.000006269745,0.00003679319,0.00002674709,0.00001660058,0.00004503448,8.170714e-7,0.9919102,0.006238219,0.0008408226,0.0001915632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9519772,0.001034517,0.04260569,0.0001371821,0.00001664034,0.0003828657,0.00001436016,0.00001840236,0.003813167],"genre_scores_gemma":[0.9810451,0.0001128269,0.01821619,0.0001042221,0.0001429221,0.00007256606,0.00007079853,0.0000237929,0.0002115862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02906792,"threshold_uncertainty_score":0.6469549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013880782263068,"score_gpt":0.214089699040205,"score_spread":0.200208916777137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}