{"id":"W2171258357","doi":"10.1351/pac200476071579","title":"Minimalist proteins: Design of new molecular recognition scaffolds","year":2004,"lang":"en","type":"article","venue":"Pure and Applied Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; DNA; Footprinting; Zipper; Leucine zipper; bZIP domain; DNA-binding protein; Scaffold protein; Alanine; Biophysics; Biochemistry; Transcription factor; Amino acid; Gene; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00023539,0.0003147631,0.000310495,0.0001369098,0.0001509705,0.0003919583,0.0004960603,0.0003877413,0.0009676915],"category_scores_gemma":[0.0002557881,0.0002075757,0.0002123939,0.00009218058,0.0003176153,0.0004374257,0.0002486211,0.0005168745,0.000588258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004720458,"about_ca_system_score_gemma":0.0002098499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001342782,"about_ca_topic_score_gemma":0.000222651,"domain_scores_codex":[0.9998764,0.00002073291,0.000008498111,0.0000330778,0.00003981567,0.00002155721],"domain_scores_gemma":[0.9998826,0.00002148243,0.00004034873,0.00001026665,0.00001237864,0.00003280594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191177,0.00006511505,0.0003137052,0.0001706672,0.00001621448,0.00012876,0.00004750064,0.003035439,0.9820284,0.006036473,0.0002273016,0.007811254],"study_design_scores_gemma":[0.00007371081,0.0007365213,0.0008452706,0.00001864917,0.00002980871,0.0004681134,0.00004698481,0.01340583,0.9541909,0.002990816,0.02716134,0.00003215927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8770425,0.003599,0.1127061,0.0005445791,0.0000912533,0.0001767334,0.0003163318,0.0007587057,0.004764783],"genre_scores_gemma":[0.8814384,0.002261042,0.1101568,0.000255407,0.00003882545,0.000229676,0.0005163557,0.00009335493,0.005010185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009676915,"threshold_uncertainty_score":0.003424883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013880782263068,"score_gpt":0.214089699040205,"score_spread":0.200208916777137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}