{"id":"W2171321165","doi":"10.1124/jpet.103.059824","title":"Inverse Agonist Activity of Selected Ligands of the Cysteinyl-Leukotriene Receptor 1","year":2004,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Inverse agonist; Chemistry; Agonist; Receptor; Zafirlukast; Montelukast; Stereochemistry; G protein-coupled receptor; Partial agonist; Antagonist; Pharmacology; Biochemistry; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002351239,0.0003334275,0.0003997823,0.0002456579,0.0002065044,0.0002757625,0.0003053347,0.0003403977,0.003324358],"category_scores_gemma":[0.0004194551,0.0001853819,0.0002229044,0.0001505467,0.0001973229,0.0001653077,0.0001802534,0.000745901,0.0005556409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608205,"about_ca_system_score_gemma":0.0002536812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000489922,"about_ca_topic_score_gemma":0.001019077,"domain_scores_codex":[0.9997882,0.00005984896,0.00001452448,0.00002059153,0.00003022519,0.00008656232],"domain_scores_gemma":[0.999849,0.0000644432,0.00001677362,0.00001323124,0.00001510823,0.00004141016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001832931,0.0001209304,0.0002198216,0.00005960995,0.00001683378,0.0001269227,0.00003686524,0.0001744308,0.9944991,0.0002130911,0.0001219635,0.00257742],"study_design_scores_gemma":[0.0002937192,0.004993753,0.005044368,0.00002089351,0.0001242308,0.001586261,0.0001114699,0.00214986,0.9818839,0.0001733894,0.003596176,0.00002211767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995621,0.001569403,0.0006151232,0.00009041694,0.00002884414,0.00002256588,0.0001081299,0.00002785249,0.001916572],"genre_scores_gemma":[0.9944574,0.001276575,0.0008732128,0.0001010275,0.00002879019,0.00003397665,0.000533769,0.00001411756,0.002681229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003324358,"threshold_uncertainty_score":0.01112109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489200723111708,"score_gpt":0.277226569808401,"score_spread":0.2623345625772839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}