{"id":"W2171347556","doi":"10.1677/erc.0.0100561","title":"Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions.","year":2003,"lang":"en","type":"review","venue":"Endocrine Related Cancer","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cancer research; Insulin-like growth factor-binding protein; Prostate cancer; Cancer; Cell growth; Biology; Prostate; Receptor; Apoptosis; PI3K/AKT/mTOR pathway; Growth factor; Endocrinology; Internal medicine; Medicine; Signal transduction; Immunology; Cell biology; Insulin-like growth factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005845761,0.0008162732,0.00113115,0.002180147,0.0002918432,0.0007980297,0.0008530046,0.001466412,0.00396234],"category_scores_gemma":[0.0006437703,0.0002091655,0.0003080416,0.003106885,0.0005942599,0.001390388,0.000556363,0.001241619,0.00214958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007417062,"about_ca_system_score_gemma":0.001033148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001883147,"about_ca_topic_score_gemma":0.003885039,"domain_scores_codex":[0.9998329,0.00003929548,0.00001830801,0.00002554267,0.00007071015,0.0000132429],"domain_scores_gemma":[0.9997526,0.0001111567,0.00003238566,0.00000891412,0.00006686605,0.00002801917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001119549,0.00008014702,0.0003187252,0.009169512,0.00007090361,0.0004302207,0.00005908296,0.0002419561,0.001083117,0.0022256,0.03025462,0.9559542],"study_design_scores_gemma":[0.00004548477,0.0001591191,0.002453412,0.003692262,0.00009037276,0.003337716,0.000139452,0.00009121778,0.0003259928,0.002770135,0.9868764,0.00001856508],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005436995,0.9990006,0.00004022354,0.0002346213,0.0001195166,0.000001878935,0.000005727917,0.00000300667,0.000540107],"genre_scores_gemma":[0.0004862054,0.9987607,0.000094959,0.0001584188,0.0001475263,0.000003431882,0.00001067295,4.687144e-7,0.0003376698],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00396234,"threshold_uncertainty_score":0.01325536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1360404347166136,"score_gpt":0.4208137108266259,"score_spread":0.2847732761100122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}