{"id":"W2171351186","doi":"10.1016/j.vph.2015.11.001","title":"Lack of glutathione peroxidase-1 facilitates a pro-inflammatory and activated vascular endothelium","year":2015,"lang":"en","type":"article","venue":"Vascular Pharmacology","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Pakistan Atomic Energy Commission","keywords":"GPX1; Ebselen; Inflammation; Glutathione peroxidase; p38 mitogen-activated protein kinases; Nitric oxide; Chemistry; Endothelial dysfunction; MAPK/ERK pathway; Reactive oxygen species; Protein kinase B; VCAM-1; Signal transduction; ICAM-1; Cell adhesion molecule; Oxidative stress; Cell biology; Immunology; Internal medicine; Biology; Medicine; Biochemistry; Superoxide dismutase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004010432,0.000335727,0.0003406358,0.0002601148,0.0001689307,0.0005591217,0.0003453348,0.0005676857,0.001987535],"category_scores_gemma":[0.0003699393,0.000263935,0.0003890647,0.0001116713,0.0006433566,0.000480731,0.0004816584,0.001590016,0.0002950314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003366118,"about_ca_system_score_gemma":0.0003259811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002137571,"about_ca_topic_score_gemma":0.000257189,"domain_scores_codex":[0.9995891,0.0001206167,0.00003940497,0.00007409635,0.00007319219,0.0001035328],"domain_scores_gemma":[0.9995394,0.00008516115,0.0001378417,0.00008222455,0.00003281104,0.0001226473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000712775,0.00008515912,0.0003707976,0.00003753534,0.00001225497,0.0001347959,0.00002347549,0.00005263069,0.9970879,0.0005880049,0.00005984281,0.0008347291],"study_design_scores_gemma":[0.00007828631,0.0008679491,0.007436724,0.000008993928,0.00003480517,0.0009712623,0.0001013186,0.001069497,0.9873534,0.000517228,0.00155257,0.000007998106],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957486,0.0005451214,0.002633539,0.0003809631,0.00005101757,0.00001304154,0.00008372848,0.00006330846,0.0004807441],"genre_scores_gemma":[0.9972875,0.0001760801,0.0009756942,0.00007092757,0.00001642031,0.00001452198,0.0001248281,0.00001313797,0.001320976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987535,"threshold_uncertainty_score":0.006649017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03977217550675679,"score_gpt":0.2764190534249855,"score_spread":0.2366468779182287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}