{"id":"W2171352062","doi":"10.1016/j.jmb.2006.06.005","title":"Topological Information Embodied in Local Juxtaposition Geometry Provides a Statistical Mechanical Basis for Unknotting by Type-2 DNA Topoisomerases","year":2006,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Unknot; Knot (papermaking); Topoisomerase; Topology (electrical circuits); Mathematics; Combinatorics; DNA; Biology; Genetics; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003561818,0.0001364635,0.0002445689,0.0001123264,0.00005667879,0.0000181745,0.0001346213,0.0002541054,0.00001606409],"category_scores_gemma":[0.0001853811,0.0001166537,0.000107952,0.00009742736,0.00007228029,0.00001102603,0.00005731659,0.0001289326,0.000001122577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000567365,"about_ca_system_score_gemma":0.00009865493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003435583,"about_ca_topic_score_gemma":0.00002523129,"domain_scores_codex":[0.9988787,0.00009925658,0.0005153227,0.0001545518,0.0001002591,0.0002518948],"domain_scores_gemma":[0.9993628,0.0000541785,0.0002385423,0.0001021291,0.0001829856,0.00005933637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005811005,0.0001079353,0.00008872138,0.00001673851,0.00004483739,0.00000713475,0.000009498361,0.00008731554,0.9720061,0.01736289,0.0004216996,0.009266065],"study_design_scores_gemma":[0.001873481,0.003626633,0.0001306107,0.00002761203,0.00006122328,0.0001248813,0.000109689,0.000316996,0.9469415,0.01808502,0.02844249,0.00025989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.512316,0.0005723031,0.4863056,0.0003289625,0.0001865076,0.0001602511,0.00006041453,0.00000371856,0.00006625932],"genre_scores_gemma":[0.9900658,0.00007648693,0.00867039,0.0007694039,0.0001370855,0.00001325843,0.0002468819,0.00001083894,0.000009915979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4777498,"threshold_uncertainty_score":0.4757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007348551003276111,"score_gpt":0.2753388217501415,"score_spread":0.2679902707468654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}