{"id":"W2171387031","doi":"10.1158/1535-7163.1659.3.12","title":"Camptothecin- and etoposide-induced apoptosis in human leukemia cells is independent of cell death receptor-3 and -4 aggregation but accelerates tumor necrosis factor–related apoptosis-inducing ligand–mediated cell death","year":2004,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Institute of Cancer Research; Canadian Institutes of Health Research","keywords":"Camptothecin; TRADD; FADD; Apoptosis; Death domain; Programmed cell death; Biology; Fas receptor; Tumor necrosis factor alpha; Molecular biology; Cell biology; Chemistry; Cancer research; Immunology; Biochemistry; Caspase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009713494,0.0002522028,0.0002071605,0.0001780764,0.0001203344,0.0001883338,0.0001115084,0.000168922,0.0011448],"category_scores_gemma":[0.00009269024,0.0001338824,0.0002205487,0.0001625518,0.0001271024,0.0001296638,0.0001050209,0.0004709718,0.0004892232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302796,"about_ca_system_score_gemma":0.0002274628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008687087,"about_ca_topic_score_gemma":0.0009922698,"domain_scores_codex":[0.9998803,0.00002075273,0.00001658321,0.00001908796,0.0000363369,0.00002687524],"domain_scores_gemma":[0.9999456,0.00001058985,0.00001101277,0.0000127717,0.00000652221,0.00001342243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001506649,0.00003054493,0.0001569381,0.0000191677,0.000004655225,0.00005995192,0.00001663997,0.00004324839,0.9985943,0.00006311354,0.00003090057,0.0008297531],"study_design_scores_gemma":[0.00003826248,0.0002605439,0.005091547,0.00000366727,0.000008509274,0.0003601419,0.00001508733,0.0009940551,0.9915168,0.00004577895,0.001662809,0.000002813001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995536,0.001182562,0.001450325,0.00006238298,0.0000193802,0.00004304653,0.0004062403,0.00006719073,0.001232965],"genre_scores_gemma":[0.9934809,0.0008059072,0.0016174,0.00004575167,0.000009703191,0.00005713846,0.001084178,0.000009799114,0.002889296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0011448,"threshold_uncertainty_score":0.003829718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776596846621691,"score_gpt":0.2537037935416699,"score_spread":0.235937825075453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}