{"id":"W2171387445","doi":"10.1158/0008-5472.can-09-1770","title":"Suppression of Hypoxia-Inducible Factor 2α Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto; University Health Network","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Clear cell renal cell carcinoma; Cancer research; Downregulation and upregulation; Biology; Small hairpin RNA; Suppressor; Programmed cell death; Tumor suppressor gene; Chemotherapy; Hypoxia-inducible factors; Apoptosis; Cancer; Renal cell carcinoma; Pathology; Gene; Medicine; Gene knockdown; Carcinogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008381105,0.0001869652,0.0001987959,0.0001198699,0.0001028204,0.0002030156,0.0001445791,0.0001121727,0.0004961972],"category_scores_gemma":[0.00008304232,0.00008601304,0.000101948,0.00008614946,0.0001723708,0.0001102991,0.00009997654,0.0003221176,0.0001939128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032339,"about_ca_system_score_gemma":0.0001336391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004168752,"about_ca_topic_score_gemma":0.0008173372,"domain_scores_codex":[0.9999559,0.000008591182,0.000003364053,0.000007355957,0.00001334135,0.00001143105],"domain_scores_gemma":[0.9999616,0.000004370548,0.00001133419,0.00000697831,0.000004255662,0.00001138534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001227712,0.00003331382,0.0001953296,0.00001833451,0.00000546173,0.00004585152,0.000009310354,0.0001001267,0.9969906,0.00009683198,0.00007705187,0.002305049],"study_design_scores_gemma":[0.00003815654,0.0003251885,0.002602384,0.000002180848,0.00001039943,0.0002708912,0.00001437138,0.0009602347,0.9922156,0.0000409695,0.003517607,0.000002122195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961455,0.001033619,0.001581738,0.0001051912,0.00002651982,0.00001401183,0.0001157812,0.0001114521,0.0008661345],"genre_scores_gemma":[0.9972976,0.000513536,0.0007928028,0.00003586434,0.000009949096,0.00001101064,0.0002312893,0.00001114173,0.001096749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004961972,"threshold_uncertainty_score":0.001659989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04195429450530473,"score_gpt":0.343005181221167,"score_spread":0.3010508867158623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}