{"id":"W2171391341","doi":"10.1016/s0092-8674(04)00126-6","title":"Mammalian SIRT1 Represses Forkhead Transcription Factors","year":2004,"lang":"en","type":"article","venue":"Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1351,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Regional Cancer Foundation; University of Ottawa","funders":"","keywords":"Forkhead Transcription Factors; Biology; Transcription factor; FOXA2; Sirtuin 1; Cell biology; FOXO1; Saccharomyces cerevisiae; Crosstalk; Transcription (linguistics); Genetics; Gene; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002206844,0.0003573633,0.0002824641,0.0002516542,0.0002241681,0.0003264644,0.0003081808,0.0002150447,0.001411304],"category_scores_gemma":[0.0002187727,0.0001554247,0.0002376398,0.0001388485,0.0003392399,0.0002545204,0.0002732977,0.000340884,0.0005106279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005882827,"about_ca_system_score_gemma":0.0002243034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005994353,"about_ca_topic_score_gemma":0.001594616,"domain_scores_codex":[0.999905,0.0000163819,0.000005648026,0.00002640917,0.00002696366,0.00001965755],"domain_scores_gemma":[0.9998704,0.00001786357,0.00003102914,0.00002568222,0.00001990503,0.00003508489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003685171,0.00001772869,0.0006236545,0.00005194096,0.00001217756,0.00005030445,0.00001842609,0.0001091719,0.9932122,0.0008288129,0.0003042938,0.004402758],"study_design_scores_gemma":[0.00004119909,0.0001772345,0.009358194,0.000007266885,0.00002113612,0.0002137932,0.00002405414,0.0007555173,0.9801489,0.0003849037,0.008858943,0.000008854689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757411,0.01077901,0.006927887,0.0005881183,0.0002848509,0.00001301623,0.0006824273,0.0005012991,0.004482236],"genre_scores_gemma":[0.9902913,0.00210216,0.002017449,0.0001360502,0.00006622536,0.00001043695,0.0007140153,0.00005967115,0.00460275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411304,"threshold_uncertainty_score":0.004721344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354697633179145,"score_gpt":0.2206936340219448,"score_spread":0.2071466576901534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}