{"id":"W2171452890","doi":"10.1054/drup.2000.0152","title":"Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment","year":2000,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":519,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pseudomonas aeruginosa; Antibiotics; Efflux; Antibiotic resistance; Microbiology; Periplasmic space; Biology; Resistance (ecology); Bacterial outer membrane; Bacteria; Genetics; Gene; Ecology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002001156,0.0004601995,0.0004213577,0.00009441363,0.0001270956,0.0000862796,0.0002619149,0.000164994,0.0001604147],"category_scores_gemma":[0.00003446427,0.0003675903,0.0001301822,0.000208221,0.0001824957,0.00001575491,0.00003564546,0.0001115426,0.00005871807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407703,"about_ca_system_score_gemma":0.000079373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004420725,"about_ca_topic_score_gemma":0.001780643,"domain_scores_codex":[0.9978808,0.0001199863,0.000383972,0.0008430018,0.0002077777,0.0005644526],"domain_scores_gemma":[0.9989401,0.00004717878,0.0001095188,0.0007214354,0.00003836411,0.000143426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02242602,0.002998432,0.1479065,0.0006198728,0.0009849104,0.0009222954,0.001671902,0.0004812545,0.7302951,0.01973873,0.05254887,0.01940614],"study_design_scores_gemma":[0.006046035,0.000864101,0.4288797,0.0009170715,0.0001074978,0.00003078594,0.0003907942,0.00004326231,0.4490007,0.007148156,0.1042416,0.002330331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892837,0.002887888,0.00003146947,0.0005005943,0.00007738206,0.0003690494,0.00009000296,0.00003330316,0.006726648],"genre_scores_gemma":[0.9760872,0.003004349,0.002979429,0.0001776331,0.00008868348,0.00001202563,0.0001439903,0.00005368929,0.01745308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2812944,"threshold_uncertainty_score":0.9998776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00525736061795576,"score_gpt":0.2436045997669158,"score_spread":0.2383472391489601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}