{"id":"W2171461786","doi":"10.1161/01.atv.20.4.1033","title":"Rapid Restoration of Normal Endothelial Functions in Genetically Hyperlipidemic Mice by a Synthetic Mediator of Reverse Lipid Transport","year":2000,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Heart and Stroke Foundation of British Columbia and Yukon; Genentech; Heart and Stroke Foundation of Canada; National Institute of General Medical Sciences; American Heart Association","keywords":"Endothelium; Endothelial dysfunction; In vivo; Hyperlipidemia; Knockout mouse; Reverse cholesterol transport; Apolipoprotein B; Endocrinology; Vasodilation; Internal medicine; Cholesterol; Endothelial stem cell; Mediator; Biology; Medicine; Lipoprotein; Biochemistry; Diabetes mellitus; In vitro; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003468972,0.0006095637,0.000380076,0.0003966684,0.0001668703,0.0004039827,0.0003055711,0.0005578296,0.0009797595],"category_scores_gemma":[0.0002035985,0.000295426,0.0002840271,0.0001578885,0.000472035,0.0003313535,0.0002092285,0.001027181,0.0003221566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411433,"about_ca_system_score_gemma":0.0001903665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002257482,"about_ca_topic_score_gemma":0.0003610945,"domain_scores_codex":[0.9997701,0.0000580215,0.00003130019,0.00004312934,0.00004894705,0.00004841511],"domain_scores_gemma":[0.9997088,0.00003578795,0.0001228655,0.00004693966,0.00001759019,0.00006794514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003447873,0.00008077378,0.00007658755,0.00001966434,0.000005866359,0.00005503211,0.00000809065,0.00004298332,0.9984245,0.0001446511,0.00002264122,0.0007743738],"study_design_scores_gemma":[0.0001530609,0.001392939,0.001235078,0.000008736903,0.00002787114,0.0003322045,0.00001728404,0.000488829,0.9949091,0.0000938993,0.001333574,0.000007390937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926705,0.0009257343,0.00499939,0.0001708728,0.00004572011,0.00004971915,0.0002681816,0.0002083654,0.0006614903],"genre_scores_gemma":[0.989359,0.001335403,0.005456601,0.0000999367,0.00002628078,0.0001138428,0.0005538298,0.00006182741,0.002993379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009797595,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250291671859805,"score_gpt":0.2301584051502721,"score_spread":0.2176554884316741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}