{"id":"W2171534580","doi":"10.3899/jrheum.130378","title":"Potential Role of Hyaluronic Acid on Bone in Osteoarthritis: Matrix Metalloproteinases, Aggrecanases, and RANKL Expression are Partially Prevented by Hyaluronic Acid in Interleukin 1-stimulated Osteoblasts","year":2014,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hyaluronic acid; Medicine; Matrix metalloproteinase; RANKL; Osteoarthritis; Bone matrix; Interleukin; Immunology; Cancer research; Internal medicine; Cell biology; Endocrinology; Cartilage; Pathology; Cytokine; Receptor; Anatomy; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002363209,0.0004586175,0.000444427,0.0002229818,0.0001426642,0.0002521394,0.000190131,0.0003494441,0.001305709],"category_scores_gemma":[0.0001466287,0.000159944,0.0004291447,0.0001517622,0.0003667726,0.0002198846,0.0002118019,0.0004248293,0.0002744811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001159839,"about_ca_system_score_gemma":0.0002933122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000373551,"about_ca_topic_score_gemma":0.000721053,"domain_scores_codex":[0.9998139,0.00003740972,0.00002110288,0.00002089843,0.00005756463,0.00004914358],"domain_scores_gemma":[0.9998401,0.00001484937,0.00006090945,0.00001574718,0.00002162363,0.00004679925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005914209,0.00005043866,0.0002408484,0.0001759065,0.00001369858,0.00009777518,0.00001744738,0.00001665487,0.9970345,0.0000302626,0.00001679994,0.00171416],"study_design_scores_gemma":[0.0001216973,0.002085493,0.01362283,0.00002576053,0.00007137628,0.0004283666,0.00007048299,0.0001813748,0.9816404,0.00005995241,0.001685398,0.000006808418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981894,0.01598251,0.001110227,0.0001106608,0.00003538504,0.00003178956,0.0002238196,0.00003528058,0.0005763493],"genre_scores_gemma":[0.9921955,0.004425744,0.0009428232,0.00005234608,0.00002479883,0.00004807186,0.0002413815,0.000006959172,0.002062307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001305709,"threshold_uncertainty_score":0.004368007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003405585891246084,"score_gpt":0.229422870328206,"score_spread":0.22601728443696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}