{"id":"W2171575763","doi":"10.1002/chem.201303928","title":"Synthesis of 2,5‐Diaryl‐Substituted Thiophenes as Helical Mimetics: Towards the Modulation of Islet Amyloid Polypeptide (IAPP) Amyloid Fibril Formation and Cytotoxicity","year":2014,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Sulfur-Based Synthesis Techniques","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Thioflavin; Islet; Amyloid (mycology); Cytotoxicity; Fibril; Amyloid fibril; Fluorescence; Peptide; Biophysics; Cytotoxic T cell; Biochemistry; In vitro; Amyloid β; Internal medicine; Biology; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001739366,0.0004239405,0.0002369351,0.0001679126,0.0001000864,0.0001330457,0.0002387799,0.0002788284,0.0006914463],"category_scores_gemma":[0.0001133184,0.0001543559,0.0001912129,0.0001952643,0.0001116149,0.0001831087,0.0001523575,0.0002810364,0.0002869788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150056,"about_ca_system_score_gemma":0.000155436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001589236,"about_ca_topic_score_gemma":0.000291194,"domain_scores_codex":[0.9999374,0.00001565151,0.000006041267,0.00001214953,0.00001430391,0.00001443329],"domain_scores_gemma":[0.9999431,0.0000103954,0.00001651724,0.000006478966,0.0000104642,0.00001297577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009037495,0.0000209212,0.00004879075,0.00008448395,0.000007006287,0.0001170908,0.0000375683,0.0004686624,0.9964474,0.0002006654,0.00004421636,0.002432791],"study_design_scores_gemma":[0.00002473921,0.0006838949,0.0004467447,0.000006225025,0.00001452312,0.0001962001,0.0000137337,0.0007929073,0.9953148,0.00004519429,0.002454754,0.000006266177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841463,0.002775962,0.01004305,0.00006430018,0.00003198948,0.0001114031,0.00025317,0.00009529979,0.002478449],"genre_scores_gemma":[0.9848797,0.003243162,0.009116968,0.00006351502,0.00001582094,0.0001200671,0.0002800117,0.00001855689,0.002262177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006914463,"threshold_uncertainty_score":0.002313137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01563890242502679,"score_gpt":0.2248642433245019,"score_spread":0.2092253408994751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}