{"id":"W2171595628","doi":"10.1126/science.1191026","title":"Phosphatidic Acid Is a pH Biosensor That Links Membrane Biogenesis to Metabolism","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Phosphatidic acid; Phospholipid; Metabolism; Intracellular; Biochemistry; Lipid metabolism; Cytosol; Cell biology; Phospholipase D; Chemistry; Biology; Membrane; Signal transduction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757964,0.000423337,0.0003078921,0.0002675484,0.0002305777,0.0005526072,0.0003293037,0.0004728479,0.0009404868],"category_scores_gemma":[0.0002516039,0.0002951512,0.0001553711,0.000235515,0.0003749906,0.0004338515,0.0004479352,0.0006105726,0.0005283356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004803289,"about_ca_system_score_gemma":0.0001760914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004954016,"about_ca_topic_score_gemma":0.0005917097,"domain_scores_codex":[0.9998112,0.00002291751,0.00001204221,0.00006734003,0.00006369444,0.00002280299],"domain_scores_gemma":[0.9999082,0.00002451481,0.00002102263,0.00001041792,0.00001252999,0.00002329844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005394565,0.000004906926,0.0001097819,0.00001816388,0.000001785381,0.00001824388,0.000003521283,0.00003054293,0.9988309,0.0001356018,0.00002855174,0.000764139],"study_design_scores_gemma":[0.00000824476,0.00004296346,0.001101851,0.000002334666,0.000004344907,0.0002255895,0.000009615772,0.0008412322,0.9962154,0.0001662427,0.001376564,0.000005661328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9320254,0.007054154,0.05354987,0.001040729,0.000223132,0.00005674949,0.001062332,0.0006685385,0.004319131],"genre_scores_gemma":[0.9776888,0.002645588,0.01517436,0.0001840014,0.00004718352,0.00002957302,0.0008916421,0.00004305715,0.003295771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009404868,"threshold_uncertainty_score":0.003485024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015305110604826,"score_gpt":0.2454525899153801,"score_spread":0.2352995388093319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}