{"id":"W2171600086","doi":"10.1182/blood-2012-09-457747","title":"Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"","keywords":"Hedgehog; Stem cell; Induced pluripotent stem cell; Haematopoiesis; Biology; Cell biology; Hedgehog signaling pathway; Embryonic stem cell; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008482049,0.0001522401,0.00018296,0.00006669266,0.00006196797,0.00001865916,0.00005310885,0.0001012722,0.000006998179],"category_scores_gemma":[0.00002661473,0.0001482155,0.00003442192,0.00008862559,0.00008579601,0.000006968426,0.0001320325,0.00005468447,0.000007335914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001210489,"about_ca_system_score_gemma":0.00002768164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000778013,"about_ca_topic_score_gemma":0.00005478329,"domain_scores_codex":[0.9990399,0.00003927984,0.0003202941,0.0002623746,0.0001162163,0.0002219532],"domain_scores_gemma":[0.9996258,0.00001277345,0.00009945918,0.00009907415,0.0001063555,0.00005655562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006071184,0.0002762709,0.01683667,0.0001085078,0.00007190026,0.000007659455,0.0004552867,0.000001363364,0.9816644,0.000006321077,0.00003624024,0.0005292824],"study_design_scores_gemma":[0.001407085,0.0001591598,0.006388223,0.0001117303,0.0000188587,0.000009720493,0.001032702,0.000003471387,0.9906248,0.00001931417,0.00005924448,0.0001657266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990641,0.0003677536,0.00001862764,0.00001842662,0.00002576308,0.000363225,0.00001304883,0.00001426457,0.00011477],"genre_scores_gemma":[0.9988375,0.00005620698,0.0008187277,0.00004908945,0.00002634677,0.0001014766,0.00005850994,0.00001759,0.0000345449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01044844,"threshold_uncertainty_score":0.6044052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085714653893083,"score_gpt":0.213393625821075,"score_spread":0.2025364792821442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}