{"id":"W2171600156","doi":"10.1038/srep09257","title":"SNP genotyping using TaqMan® technology: the CYP2D6*17 assay conundrum","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute on Drug Abuse; National Institute of Mental Health; National Institutes of Health","keywords":"TaqMan; Genotyping; Genotype; SNP genotyping; Biology; Locus (genetics); Genetics; CYP2D6; SNP; Primer (cosmetics); Single-nucleotide polymorphism; Computational biology; Gene; Allele; Polymerase chain reaction; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01302005,0.0009774086,0.00167761,0.001875119,0.0005843694,0.002147237,0.001693346,0.003284074,0.005925385],"category_scores_gemma":[0.00998021,0.001222383,0.001055734,0.001903713,0.00168855,0.0008339699,0.001262285,0.003075375,0.006868122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007316999,"about_ca_system_score_gemma":0.001671095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006233928,"about_ca_topic_score_gemma":0.001042777,"domain_scores_codex":[0.9721503,0.01061773,0.001559476,0.004836422,0.0100063,0.0008296903],"domain_scores_gemma":[0.9942356,0.002357102,0.0008440642,0.001116428,0.001135636,0.0003111557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00106884,0.0005761673,0.0525111,0.001482566,0.0004914702,0.001202045,0.001152486,0.001297161,0.5074844,0.0152849,0.0428516,0.3745973],"study_design_scores_gemma":[0.000482532,0.004444825,0.04836086,0.0006645577,0.0004928007,0.01359738,0.000296275,0.01707362,0.3847506,0.01748984,0.5120644,0.0002822868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.09224713,0.01226469,0.8398689,0.008676512,0.00308194,0.002578036,0.007434534,0.007754915,0.02609338],"genre_scores_gemma":[0.2160779,0.00713631,0.7028507,0.009659516,0.001250118,0.005444749,0.009803119,0.0009262408,0.04685134],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01302005,"threshold_uncertainty_score":0.06885743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2331709047025464,"score_gpt":0.4530663668042264,"score_spread":0.21989546210168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}