{"id":"W2171622061","doi":"10.1242/bio.20147021","title":"Aggresome formation is regulated by RanBPM through an interaction with HDAC6","year":2014,"lang":"en","type":"article","venue":"Biology Open","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Robarts Research Institute; Canadian Institutes of Health Research","keywords":"Aggresome; HDAC6; MG132; Cell biology; Biology; Histone deacetylase; Ubiquitin; Cancer research; Microtubule; Proteasome; Proteasome inhibitor; Histone; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525565,0.0003899433,0.0002938445,0.0002142815,0.0003420387,0.0003100451,0.000199084,0.0001938592,0.001062926],"category_scores_gemma":[0.00008487026,0.0001764249,0.0003824461,0.000122433,0.0002071972,0.0001562634,0.0002636814,0.0003087652,0.0006893274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003511566,"about_ca_system_score_gemma":0.000120712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004542042,"about_ca_topic_score_gemma":0.0008643821,"domain_scores_codex":[0.9998401,0.0000295003,0.00001601424,0.00004082873,0.00004241586,0.00003105659],"domain_scores_gemma":[0.9999098,0.000005392088,0.00003619274,0.00001075091,0.00001349144,0.00002435766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006480669,0.000009856204,0.000321802,0.0000253396,0.000005937268,0.00008269115,0.000006554468,0.00001593205,0.9988546,0.00005366871,0.00003018145,0.0005286422],"study_design_scores_gemma":[0.000009225451,0.00008032945,0.0178387,0.000006492655,0.0000139397,0.0004282716,0.00002128988,0.0005924953,0.9782937,0.00004328187,0.00266802,0.000004253916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867446,0.004389085,0.005727305,0.0001395988,0.00004106684,0.00002389525,0.0003614545,0.0001682615,0.002404785],"genre_scores_gemma":[0.9922757,0.001252181,0.002597887,0.00004084121,0.00001746343,0.00002694219,0.0005131344,0.00002539422,0.003250417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001062926,"threshold_uncertainty_score":0.003555834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287840155600689,"score_gpt":0.2995162520405991,"score_spread":0.2766378504845922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}