{"id":"W2171657654","doi":"10.1002/mrd.10202","title":"Targeting gene expression in the preimplantation mouse embryo using morpholino antisense oligonucleotides","year":2002,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Morpholino; Embryo; Oligonucleotide; Gene expression; Gene; Genetics; Cell biology; Andrology; Computational biology; Gene knockdown","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001759698,0.0003344511,0.0001736955,0.0001878888,0.0001149894,0.0002464525,0.0001777517,0.000240525,0.0007980532],"category_scores_gemma":[0.0001444111,0.0002035178,0.0001240886,0.00008084967,0.000188507,0.0001384734,0.0001174318,0.0005027177,0.0003893432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143038,"about_ca_system_score_gemma":0.00018921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003417095,"about_ca_topic_score_gemma":0.0006995481,"domain_scores_codex":[0.999871,0.000015748,0.00001589166,0.00003711881,0.00004189139,0.00001837481],"domain_scores_gemma":[0.9999002,0.00002771891,0.00003230484,0.00000842906,0.00001628144,0.00001501919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007249721,0.000001850812,0.00002298974,0.000007177467,4.554796e-7,0.000007206865,0.000002823024,0.000007684335,0.9996248,0.00002042148,0.000003899628,0.0002933933],"study_design_scores_gemma":[0.000004215195,0.000100662,0.001233341,0.000002239463,0.000005711426,0.00007636449,0.000006339837,0.0001103996,0.9971099,0.0000152968,0.001334314,0.000001200005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724507,0.003178392,0.02036552,0.0001287272,0.00006526185,0.0001393619,0.0004300202,0.000221898,0.003020081],"genre_scores_gemma":[0.9521064,0.004619978,0.03162936,0.0001392504,0.00003488442,0.0002583802,0.001087214,0.00008664877,0.01003795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007980532,"threshold_uncertainty_score":0.002669752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828493970615494,"score_gpt":0.2613773994896073,"score_spread":0.2330924597834524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}