{"id":"W2171661161","doi":"10.2337/db11-1341","title":"Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired β-Cell Function","year":2012,"lang":"en","type":"article","venue":"Diabetes","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Universitair Medisch Centrum Groningen; Heart and Stroke Foundation of Canada; Killam Trusts; Michael Smith Health Research BC; Canadian Diabetes Association; Wake Forest University","keywords":"ABCA1; ABCG1; Internal medicine; Endocrinology; Glucose homeostasis; Biology; Tangier disease; Islet; Cholesterol; Homeostasis; Transporter; Insulin; Insulin resistance; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773669,0.0005897481,0.0005341297,0.0007635593,0.0001755833,0.0005140716,0.0002119292,0.0004731513,0.001324648],"category_scores_gemma":[0.000154953,0.0002158288,0.0002420094,0.0004973779,0.0005201775,0.0002313394,0.000354504,0.0009974379,0.0004287221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003410709,"about_ca_system_score_gemma":0.0002145722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005141089,"about_ca_topic_score_gemma":0.0005659768,"domain_scores_codex":[0.999756,0.00004282666,0.00002271286,0.00005227933,0.00007693208,0.00004912964],"domain_scores_gemma":[0.9997762,0.00002265575,0.00008326843,0.00002291221,0.00001605056,0.00007885494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006099165,0.00007752462,0.001879968,0.00009987811,0.0000322438,0.0003988185,0.00001782976,0.00006353345,0.9891863,0.0003253218,0.0001780367,0.007130568],"study_design_scores_gemma":[0.0003197144,0.001395288,0.100211,0.00006296258,0.0002399229,0.008647701,0.0001635931,0.001361719,0.8641016,0.0009412103,0.02252042,0.00003484832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860604,0.007681408,0.003206472,0.0004687461,0.00006785868,0.00003019689,0.0003431204,0.000215047,0.001926815],"genre_scores_gemma":[0.9894099,0.00489653,0.00229496,0.0002464044,0.00002834366,0.00006649047,0.0004091497,0.00005367295,0.002594529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324648,"threshold_uncertainty_score":0.004431427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00840588296918881,"score_gpt":0.2207876514913877,"score_spread":0.2123817685221989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}