{"id":"W2171661161","doi":"10.2337/db11-1341","title":"Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired β-Cell Function","year":2012,"lang":"en","type":"article","venue":"Diabetes","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Universitair Medisch Centrum Groningen; Heart and Stroke Foundation of Canada; Killam Trusts; Michael Smith Health Research BC; Canadian Diabetes Association; Wake Forest University","keywords":"ABCA1; ABCG1; Internal medicine; Endocrinology; Glucose homeostasis; Biology; Tangier disease; Islet; Cholesterol; Homeostasis; Transporter; Insulin; Insulin resistance; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004771663,0.0001230018,0.0003249256,0.0001796952,0.00001759611,0.00001355566,0.00002885375,0.00007417735,0.000004637105],"category_scores_gemma":[0.000114602,0.0001017311,0.00002187427,0.0001716291,0.00007890551,0.0002669288,0.00002777378,0.0001030392,0.000001591176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001592856,"about_ca_system_score_gemma":0.00001524177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000209224,"about_ca_topic_score_gemma":0.00007611535,"domain_scores_codex":[0.9990513,0.0000716439,0.0003522437,0.0001648633,0.0001286493,0.0002312597],"domain_scores_gemma":[0.9994996,0.0001090672,0.0001147955,0.0001482379,0.00002747252,0.0001008751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002857202,0.0001253664,0.9588806,0.0002523221,0.00001189816,8.405743e-7,0.001173608,6.370337e-7,0.02914613,0.00001736329,0.0001024921,0.01000302],"study_design_scores_gemma":[0.004746069,0.0001165174,0.9763748,0.0001533481,0.00004131272,9.322652e-7,0.0001443146,0.00005507686,0.01600165,0.00004598696,0.002228456,0.0000915445],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921848,0.007023367,0.000001441012,0.0002301342,0.0001021214,0.0002586432,0.00003182378,0.0000143721,0.0001532966],"genre_scores_gemma":[0.9992172,0.0003214801,0.00004629722,0.0001034178,0.0001907001,0.000019187,0.00005681867,0.00001037929,0.00003456311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01749419,"threshold_uncertainty_score":0.4148473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00840588296918881,"score_gpt":0.2207876514913877,"score_spread":0.2123817685221989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}