{"id":"W2171704260","doi":"10.1039/c0lc00487a","title":"A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment","year":2010,"lang":"en","type":"article","venue":"Lab on a Chip","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Vinculin; Mechanotransduction; Optical tweezers; Focal adhesion; Extracellular matrix; Microfluidics; Integrin; Adhesion; Fibronectin; Materials science; Biophysics; Nanotechnology; Membrane; Chemistry; Cell biology; Cell adhesion; Receptor; Optics; Cell; Biology; Composite material; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338687,0.0001222826,0.00009945485,0.00004023207,0.00008600421,0.00002843547,0.00006384573,0.00008154198,0.00001683695],"category_scores_gemma":[0.00001217963,0.00009650965,0.00003132426,0.00005888084,0.00001186555,0.000002585899,0.00003494163,0.0001338363,0.00001760069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000125308,"about_ca_system_score_gemma":0.00001946061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002015413,"about_ca_topic_score_gemma":0.00007629105,"domain_scores_codex":[0.9992791,0.00003373681,0.000111119,0.000328221,0.0001060333,0.0001417933],"domain_scores_gemma":[0.9995649,0.000005811027,0.00002396463,0.0002499358,0.00003779257,0.0001175299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000278102,0.0002177712,0.00008341631,0.000008140702,0.00003964937,0.000007230509,0.00008980103,0.000001265691,0.9961289,0.0007701879,0.0002199156,0.002155673],"study_design_scores_gemma":[0.0007689896,0.003017543,0.0004639169,0.0000238992,0.00003656657,0.0000640873,0.0005282455,0.00003858623,0.9763268,0.000007376115,0.01856764,0.0001563944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965321,0.00005049015,0.001959509,0.0002213706,0.0003057175,0.0006333383,0.000006580947,0.00001727165,0.0002736595],"genre_scores_gemma":[0.9989567,0.00002581368,0.0003880062,0.0001621935,0.0001301698,0.0001087719,0.00002070223,0.00001959593,0.0001880827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0198021,"threshold_uncertainty_score":0.3935549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717939261746797,"score_gpt":0.2591787951977471,"score_spread":0.2419994025802791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}