{"id":"W2171704260","doi":"10.1039/c0lc00487a","title":"A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment","year":2010,"lang":"en","type":"article","venue":"Lab on a Chip","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Vinculin; Mechanotransduction; Optical tweezers; Focal adhesion; Extracellular matrix; Microfluidics; Integrin; Adhesion; Fibronectin; Materials science; Biophysics; Nanotechnology; Membrane; Chemistry; Cell biology; Cell adhesion; Receptor; Optics; Cell; Biology; Composite material; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004597327,0.0007505092,0.000389761,0.0005595891,0.0005165078,0.0003907802,0.001134869,0.0006516429,0.001832271],"category_scores_gemma":[0.0003905024,0.0003971503,0.0003037627,0.0002335076,0.0004757513,0.0004907475,0.0005311762,0.0005306076,0.000528324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007611706,"about_ca_system_score_gemma":0.0006786146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009999879,"about_ca_topic_score_gemma":0.001401713,"domain_scores_codex":[0.9995901,0.00003151421,0.00002488826,0.0001376597,0.0001689928,0.00004691095],"domain_scores_gemma":[0.9997965,0.00008210667,0.00003553956,0.00002600291,0.00002780833,0.00003215019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003394933,0.00004502689,0.0001759268,0.00006989475,0.00001042788,0.00004673156,0.00002052879,0.0004042569,0.9854655,0.001496974,0.00065386,0.01157697],"study_design_scores_gemma":[0.00007401785,0.0003378452,0.001846082,0.00001384384,0.00003711522,0.0004911239,0.000007891653,0.01592682,0.938895,0.0004628393,0.04185288,0.0000545738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2672658,0.006394078,0.706538,0.001600924,0.001556532,0.001007585,0.001765489,0.005001849,0.008869787],"genre_scores_gemma":[0.4003131,0.002009058,0.5818257,0.0006080168,0.0002875517,0.002305355,0.0005978555,0.0001141063,0.01193915],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001832271,"threshold_uncertainty_score":0.006129563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717939261746797,"score_gpt":0.2591787951977471,"score_spread":0.2419994025802791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}