{"id":"W2171706231","doi":"10.1074/jbc.m411787200","title":"Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Protein kinase B; GATA4; PI3K/AKT/mTOR pathway; Gene knockdown; Biology; Wortmannin; Signal transduction; Endocrinology; Internal medicine; LY294002; Molecular biology; Transcription factor; Cell biology; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051339,0.000445291,0.0002260381,0.000315194,0.0001269603,0.0002141379,0.0001076203,0.0002172594,0.001314125],"category_scores_gemma":[0.0001052679,0.0001504942,0.0002473364,0.0001800206,0.0001773615,0.0001437872,0.0001583199,0.0005299968,0.0003731309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668342,"about_ca_system_score_gemma":0.0001769146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001934148,"about_ca_topic_score_gemma":0.0002386086,"domain_scores_codex":[0.999892,0.00001482416,0.00001114748,0.00002431118,0.00002796146,0.00002968477],"domain_scores_gemma":[0.9999058,0.00001255715,0.00004033674,0.000004941004,0.00001320688,0.00002313657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008484098,0.000190022,0.01075017,0.0003344175,0.00004150808,0.001002791,0.00005450019,0.0001437305,0.955314,0.0002370584,0.0005600434,0.0305234],"study_design_scores_gemma":[0.0004079101,0.004344155,0.2201872,0.000127366,0.0002488831,0.01657705,0.0001657922,0.002616645,0.7139936,0.0008799548,0.04040566,0.00004578767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518082,0.03274146,0.007856353,0.0005812917,0.0002404034,0.0001855813,0.001358804,0.0002937568,0.004934222],"genre_scores_gemma":[0.9766105,0.01519688,0.00416546,0.0002150957,0.0001620909,0.000116183,0.00116218,0.00001961198,0.002351888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314125,"threshold_uncertainty_score":0.0043962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03525965004308319,"score_gpt":0.2671832181204816,"score_spread":0.2319235680773984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}