{"id":"W2171706231","doi":"10.1074/jbc.m411787200","title":"Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Protein kinase B; GATA4; PI3K/AKT/mTOR pathway; Gene knockdown; Biology; Wortmannin; Signal transduction; Endocrinology; Internal medicine; LY294002; Molecular biology; Transcription factor; Cell biology; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005299686,0.0005344916,0.0007287794,0.00004862507,0.0001039098,0.00008476075,0.0008159075,0.0006203692,0.0001600077],"category_scores_gemma":[0.0005530724,0.0004241165,0.0005782066,0.0002228969,0.000254483,0.00002874036,0.0003045246,0.0006776328,0.000009840071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002531703,"about_ca_system_score_gemma":0.0004477586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002287586,"about_ca_topic_score_gemma":0.000001574619,"domain_scores_codex":[0.9970604,0.0001107557,0.0009434436,0.0007024193,0.0005339871,0.0006489465],"domain_scores_gemma":[0.9981155,0.00007695515,0.0006647903,0.0005407934,0.0002816139,0.0003203759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008922974,0.000478683,0.006064071,0.0001034015,0.0001727081,0.001066965,0.000145976,0.0006881138,0.9897451,0.000008424539,0.0002940838,0.0003401999],"study_design_scores_gemma":[0.002749778,0.0006658448,0.0004090789,0.0004299384,0.00005069972,0.0005455494,0.0002460431,0.000004035287,0.9906392,0.0006172079,0.003125963,0.000516629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918761,0.006274079,0.0005284838,0.0003417969,0.0002432524,0.0002402698,0.0001388859,0.00002976641,0.000327328],"genre_scores_gemma":[0.9964274,0.0002940086,0.001525596,0.0007894746,0.0007339167,0.000029177,0.00009202443,0.00004963985,0.00005881686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00598007,"threshold_uncertainty_score":0.9998211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03525965004308319,"score_gpt":0.2671832181204816,"score_spread":0.2319235680773984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}