{"id":"W2171720818","doi":"10.1177/1470320310392618","title":"Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors","year":2011,"lang":"en","type":"article","venue":"Journal of the Renin-Angiotensin-Aldosterone System","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Enalapril; Renin–angiotensin system; Losartan; Renin inhibitor; Blood pressure; Endocrinology; Internal medicine; Plasma renin activity; Aliskiren; Medicine; Pharmacology; Angiotensin-converting enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004240818,0.0004814616,0.001986915,0.0004071505,0.0003407591,0.00003019352,0.0004618204,0.0002960213,0.000008922164],"category_scores_gemma":[0.0008457325,0.0002725224,0.0009998099,0.000580697,0.0004009786,0.0002848345,0.0001994948,0.0003837163,0.00000282448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004596072,"about_ca_system_score_gemma":0.0006331654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001443146,"about_ca_topic_score_gemma":0.00003356652,"domain_scores_codex":[0.9939908,0.0007881592,0.002544581,0.0003748547,0.001807062,0.0004945315],"domain_scores_gemma":[0.9852375,0.0003882831,0.004574218,0.001016839,0.008635715,0.0001474051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00190062,0.0002189159,0.009219187,0.0002100828,0.002375587,0.00001735672,0.009511692,0.000402768,0.9686067,0.000245957,0.006790088,0.0005010512],"study_design_scores_gemma":[0.0102492,0.002511506,0.1014608,0.007762575,0.01174469,0.002417064,0.003552419,0.01860722,0.8406929,0.0001436121,0.0002485538,0.0006094557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898158,0.001736948,0.001547487,0.00163846,0.001726803,0.003181303,0.00007685611,0.00002688865,0.0002494177],"genre_scores_gemma":[0.9972249,0.00002821186,0.001381011,0.00008960515,0.0004027681,0.00003577787,0.00001249264,0.00009009705,0.0007351674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1279138,"threshold_uncertainty_score":0.9999727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08066066435483185,"score_gpt":0.2900438859520802,"score_spread":0.2093832215972483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}