{"id":"W2171774303","doi":"10.1371/journal.ppat.1003734","title":"Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Weill Cornell Medical College; School of Medicine, New York University; National Institutes of Health; University of Leicester; National Human Genome Research Institute; Memorial Sloan-Kettering Cancer Center; Doris Duke Charitable Foundation; York University; Infectious Diseases Society of America","keywords":"ESCRT; Endosome; Secretion; Cell biology; Effector; Biology; Lysosome; Phagolysosome; Phagosome; Microbiology; Intracellular; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088513,0.0002479392,0.0002155442,0.0001005318,0.0000976895,0.0002992843,0.0001481043,0.0002828813,0.0006754845],"category_scores_gemma":[0.00007596226,0.0001024078,0.0002194004,0.00008106815,0.000144104,0.0001008489,0.0002662955,0.0003842474,0.000422054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002913973,"about_ca_system_score_gemma":0.0001125742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267403,"about_ca_topic_score_gemma":0.000455942,"domain_scores_codex":[0.999863,0.00002062853,0.00001441995,0.00002232281,0.00005125497,0.00002831815],"domain_scores_gemma":[0.999966,0.00000578421,0.00001079446,0.00000420509,0.000003473054,0.000009658724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003308673,0.00001897556,0.0001912547,0.00001373444,0.000003927256,0.00005692648,0.000005593293,0.00005917532,0.9988986,0.00007312831,0.00003523257,0.0006102566],"study_design_scores_gemma":[0.000008058207,0.0001097578,0.003129971,0.000003456773,0.000006173294,0.0002055812,0.00001525446,0.001653706,0.9930334,0.00002361645,0.001808194,0.000002823961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952409,0.001113125,0.002307426,0.000126406,0.00002824138,0.00001793868,0.0002082273,0.0000931076,0.000864552],"genre_scores_gemma":[0.9944905,0.0005243727,0.001560942,0.00008610109,0.000006190269,0.00001346764,0.0003463279,0.00002440508,0.002947664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006754845,"threshold_uncertainty_score":0.002259672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00889884778471775,"score_gpt":0.2220486251832259,"score_spread":0.2131497773985082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}