{"id":"W2171774303","doi":"10.1371/journal.ppat.1003734","title":"Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Weill Cornell Medical College; School of Medicine, New York University; National Institutes of Health; University of Leicester; National Human Genome Research Institute; Memorial Sloan-Kettering Cancer Center; Doris Duke Charitable Foundation; York University; Infectious Diseases Society of America","keywords":"ESCRT; Endosome; Secretion; Cell biology; Effector; Biology; Lysosome; Phagolysosome; Phagosome; Microbiology; Intracellular; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001636768,0.000316452,0.000318723,0.00009157498,0.000126597,0.00007916836,0.0002338864,0.0002192561,0.0003551514],"category_scores_gemma":[0.0002403467,0.0002948372,0.0001976257,0.000242373,0.00003884893,0.000008116132,0.0001530416,0.0001476651,0.0007600693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000231585,"about_ca_system_score_gemma":0.00004579977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005052361,"about_ca_topic_score_gemma":0.000009176407,"domain_scores_codex":[0.9982622,0.0001244387,0.0002824536,0.0005777573,0.0002118507,0.0005413188],"domain_scores_gemma":[0.998808,0.0000268746,0.00007088992,0.0005227608,0.0002374506,0.0003340234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005860872,0.0000927786,0.002305929,0.00003549513,0.0001138982,0.000007241798,0.0001448162,0.00002711906,0.9932982,0.000003309088,0.002977295,0.000935297],"study_design_scores_gemma":[0.0005168055,0.0007006114,0.04429913,0.0000482548,0.0001244692,0.0000169849,0.00005606006,0.0003536186,0.9409749,0.000005337281,0.01229678,0.0006070794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975021,0.0005791545,0.0001795712,0.0002069514,0.0005202232,0.0005403045,0.0001068895,0.0000975741,0.000267206],"genre_scores_gemma":[0.9967465,0.00007059622,0.001001513,0.0007424661,0.0007694293,0.00008335836,0.0002549684,0.00008307333,0.0002481347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05232335,"threshold_uncertainty_score":0.9999503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00889884778471775,"score_gpt":0.2220486251832259,"score_spread":0.2131497773985082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}