{"id":"W2171780940","doi":"10.1146/annurev.biochem.76.010307.145803","title":"Lipid A Modification Systems in Gram-Negative Bacteria","year":2007,"lang":"en","type":"review","venue":"Annual Review of Biochemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1324,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Lipid A; Bacterial outer membrane; Inner membrane; Lipopolysaccharide; Biochemistry; Lipid II; Gram-negative bacteria; Lipid bilayer; Escherichia coli; Chemistry; Periplasmic space; Cell envelope; Enzyme; Bacteria; Membrane fluidity; Biology; Membrane; Biosynthesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004737199,0.001360045,0.001246216,0.001942405,0.0005925804,0.0009820374,0.001074988,0.00156972,0.002001714],"category_scores_gemma":[0.0003519615,0.0005115974,0.0003821633,0.002243843,0.0006702857,0.001513769,0.0008318797,0.001428793,0.005061081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001101245,"about_ca_system_score_gemma":0.0009853542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400417,"about_ca_topic_score_gemma":0.001239846,"domain_scores_codex":[0.9998011,0.00002395187,0.00002241894,0.00004422565,0.00008872125,0.00001969512],"domain_scores_gemma":[0.9998739,0.00003466869,0.00002671511,0.000008094394,0.00003561102,0.00002096917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001039793,0.000140846,0.000162141,0.01266006,0.00004668512,0.0006635922,0.0001135063,0.0008344931,0.034904,0.01063851,0.02272014,0.917012],"study_design_scores_gemma":[0.00001465368,0.0001348845,0.0003719844,0.0009381197,0.00003071651,0.001358848,0.0000341119,0.00009471704,0.005619838,0.00243469,0.9889451,0.00002246914],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005010398,0.9959423,0.0004947222,0.0001626123,0.0002482419,0.00001249108,0.00001872209,0.00002381358,0.002596061],"genre_scores_gemma":[0.00200822,0.9946063,0.0007928516,0.0001868953,0.0001476018,0.00002135632,0.00004497631,0.000004063211,0.002187682],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002001714,"threshold_uncertainty_score":0.007990122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02559404718910352,"score_gpt":0.3344980685156246,"score_spread":0.3089040213265211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}