{"id":"W2171783170","doi":"10.1093/qjmed/hcr105","title":"Bortezomib in a phase 1 trial for patients with relapsed AL amyloidosis: cardiac responses and overall effects","year":2011,"lang":"en","type":"article","venue":"QJM","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Bortezomib; AL amyloidosis; Medicine; Multiple myeloma; Amyloidosis; Internal medicine; Oncology; Cardiac amyloidosis; Clinical trial; Immunoglobulin light chain; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00209486,0.001379016,0.001882263,0.0003824711,0.0004195219,0.0009528002,0.0008036769,0.001270126,0.002608031],"category_scores_gemma":[0.001189566,0.0004013259,0.001068459,0.0003313348,0.0006142357,0.0006326577,0.0003096198,0.002922537,0.0005258783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000776472,"about_ca_system_score_gemma":0.001099289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003699794,"about_ca_topic_score_gemma":0.00102219,"domain_scores_codex":[0.9993734,0.0003776414,0.00002485602,0.00009248211,0.00004334805,0.00008827128],"domain_scores_gemma":[0.9991438,0.000191182,0.0002436986,0.00006087499,0.00004364303,0.0003167444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8322241,0.02338003,0.006989594,0.000857453,0.001115812,0.0002929154,0.0002716865,0.0023559,0.02335138,0.0002328398,0.004435249,0.104493],"study_design_scores_gemma":[0.8088846,0.1745761,0.0108707,0.00005373824,0.0003186031,0.0003545067,0.00002613242,0.0010393,0.001894511,0.0001725115,0.001791334,0.00001791011],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909684,0.005165737,0.0002827149,0.0006568331,0.0001056272,0.001110702,0.0004634201,0.00008453064,0.001162122],"genre_scores_gemma":[0.9901897,0.002409708,0.001355879,0.001033465,0.0002401178,0.00197926,0.001469398,0.00002941742,0.001293042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002608031,"threshold_uncertainty_score":0.01107883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012694486030388,"score_gpt":0.2708343802573763,"score_spread":0.2581398942269884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}