{"id":"W2171821929","doi":"10.2337/db05-1629","title":"Single Nucleotide Polymorphisms of <i>PPARD</i> in Combination With the Gly482Ser Substitution of <i>PGC-1A</i> and the Pro12Ala Substitution of <i>PPARG2</i> Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Max-Planck-Gesellschaft","keywords":"Single-nucleotide polymorphism; Internal medicine; Endocrinology; Type 2 diabetes; Genotype; Allele; Diabetes mellitus; Minor allele frequency; Peroxisome proliferator-activated receptor; Medicine; Biology; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003783745,0.0001831584,0.0002869841,0.00004705737,0.00008981185,0.00001722343,0.0002476385,0.0001137303,0.000003555453],"category_scores_gemma":[0.00007586687,0.0001010538,0.0000608808,0.0003417136,0.0007350045,0.00002814152,0.00008052523,0.0001039417,8.113329e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002279119,"about_ca_system_score_gemma":0.00006248226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001850554,"about_ca_topic_score_gemma":0.00004458334,"domain_scores_codex":[0.9987499,0.0001963978,0.0003366126,0.0002596792,0.0002351124,0.0002223562],"domain_scores_gemma":[0.999038,0.0001136495,0.0002852422,0.0003447668,0.0001857431,0.00003260496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004734499,0.0001621317,0.1042332,0.00003163037,0.00004866742,1.199503e-7,0.0001324272,0.0003008879,0.8940831,0.0001435054,0.0002061401,0.0001848033],"study_design_scores_gemma":[0.001787006,0.0004140357,0.01945095,0.0001000584,0.00005142393,2.781809e-7,0.00005774334,0.000324282,0.9768917,0.0001003169,0.0007023899,0.0001198346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959665,0.002591115,0.00004034673,0.0004652243,0.0001265334,0.0006761921,0.00006162014,0.00001007048,0.00006238173],"genre_scores_gemma":[0.999432,0.00008378395,0.00005905045,0.0001687154,0.00006236747,0.00004411041,0.000123018,0.00001656935,0.00001044685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08478222,"threshold_uncertainty_score":0.4120853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004184619666089705,"score_gpt":0.1799803902295872,"score_spread":0.1757957705634975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}