{"id":"W2171822166","doi":"10.1006/abbi.2001.2350","title":"Prevention of Staurosporine-Induced Cell Death in Embryonic Chick Cardiomyocyte Is More Dependent on Caspase-2 Than Caspase-3 Inhibition and Is Independent of Sphingomyelinase Activation and Ceramide Generation","year":2001,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Staurosporine; Ceramide; Sphingomyelin; Programmed cell death; Caspase; Apoptosis; Cell biology; Biology; Caspase 3; Caspase 8; Protein kinase C; Lipid signaling; DNA fragmentation; Biochemistry; Kinase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023172,0.000625572,0.0004992998,0.000408935,0.0002260829,0.0003285407,0.0003115551,0.0004197009,0.001918591],"category_scores_gemma":[0.0001673056,0.0003346408,0.0005039868,0.0002125774,0.0003154417,0.0003351718,0.0002317781,0.0009549427,0.000715999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004650869,"about_ca_system_score_gemma":0.0004414595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026675,"about_ca_topic_score_gemma":0.002062517,"domain_scores_codex":[0.9998108,0.00002219885,0.00003613374,0.00003360604,0.00004731318,0.00005006737],"domain_scores_gemma":[0.9997329,0.0000619849,0.00006180174,0.00005708874,0.00003056722,0.00005560743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001283415,0.00001563012,0.00007712015,0.00003696766,0.000007469564,0.00005502443,0.00001115878,0.00003010174,0.9988775,0.00008492752,0.00002080357,0.0006549658],"study_design_scores_gemma":[0.00001376158,0.0001073628,0.00150631,0.000003016256,0.00000728201,0.0001033471,0.000007208465,0.0001135263,0.9977103,0.00001282838,0.000413356,0.000001584736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873145,0.003819175,0.004997302,0.0001716529,0.00009473183,0.00006882108,0.0009178236,0.0002133472,0.00240269],"genre_scores_gemma":[0.9855414,0.00231658,0.004311049,0.00007212567,0.00001797538,0.00008444054,0.001133781,0.00005043339,0.006472226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918591,"threshold_uncertainty_score":0.006418288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134369907741844,"score_gpt":0.2400230189258805,"score_spread":0.2265860281516961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}