{"id":"W2171857206","doi":"10.1093/protein/gzp056","title":"The V119I polymorphism in protein L-isoaspartate O-methyltransferase alters the substrate-binding interface","year":2009,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health","keywords":"Chemistry; Binding site; Biophysics; Binding pocket; Active site; Substrate (aquarium); Stereochemistry; Plasma protein binding; Docking (animal); Biochemistry; Enzyme; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257336,0.0004260586,0.0003083498,0.0001276368,0.0004117389,0.0003604904,0.00054931,0.0004759353,0.002049697],"category_scores_gemma":[0.0004155732,0.0001804996,0.0004399343,0.0001769522,0.0002745798,0.000342698,0.0003074539,0.0006825246,0.0002096421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004997925,"about_ca_system_score_gemma":0.0005661414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006385906,"about_ca_topic_score_gemma":0.005518512,"domain_scores_codex":[0.9999248,0.00001290518,0.000003822636,0.0000118952,0.000016018,0.00003059064],"domain_scores_gemma":[0.9999213,0.00002593666,0.00001684267,0.000004104703,0.00001082424,0.00002097356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003457485,0.001281397,0.03485587,0.0005765856,0.000667542,0.003669619,0.0004104394,0.3827751,0.5224966,0.0190588,0.006094916,0.02465566],"study_design_scores_gemma":[0.0005552365,0.001565021,0.02276079,0.00007420598,0.0003062987,0.000629193,0.0005177866,0.8985727,0.06449972,0.003485515,0.00693,0.0001034503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951715,0.0001905324,0.002249469,0.0001357437,0.00003823264,0.00001508621,0.0001958419,0.00007531804,0.001928352],"genre_scores_gemma":[0.9971969,0.0001475247,0.001750813,0.00005510878,0.000005729141,0.00002224677,0.0003720501,0.0000339483,0.0004156873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006385906,"threshold_uncertainty_score":0.01269746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006331416393069352,"score_gpt":0.2087992576441711,"score_spread":0.2024678412511018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}