{"id":"W2171857206","doi":"10.1093/protein/gzp056","title":"The V119I polymorphism in protein L-isoaspartate O-methyltransferase alters the substrate-binding interface","year":2009,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health","keywords":"Chemistry; Binding site; Biophysics; Binding pocket; Active site; Substrate (aquarium); Stereochemistry; Plasma protein binding; Docking (animal); Biochemistry; Enzyme; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863758,0.0001415561,0.0000781027,0.00005248301,0.000141575,0.00006222386,0.00008502695,0.00009861837,0.000001312125],"category_scores_gemma":[0.00003442101,0.0001052929,0.00003050716,0.0001975391,0.00002508099,0.00000977934,0.00000769929,0.0001729449,0.000001340678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004006863,"about_ca_system_score_gemma":0.00003101031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002518347,"about_ca_topic_score_gemma":0.00002385784,"domain_scores_codex":[0.9992123,0.00007954885,0.0001697436,0.0002175008,0.00008573185,0.0002351568],"domain_scores_gemma":[0.9997847,0.00001376515,0.00003623473,0.0001043656,0.00002433657,0.00003658104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000120084,0.000009211611,0.00001054828,0.00000601687,0.00001448021,4.050548e-7,0.00005716169,0.04964823,0.9443905,0.00007813206,0.00001689829,0.00564831],"study_design_scores_gemma":[0.0003459957,0.0002761063,0.0006517475,0.00004254213,0.000007083422,0.00001397042,0.0000129057,0.03286256,0.9648407,0.00008545927,0.000714779,0.0001461967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8164258,0.001312595,0.1807602,0.0005772457,0.0000509659,0.0008360958,4.91198e-7,0.00002781202,0.000008811621],"genre_scores_gemma":[0.9986078,0.0001084684,0.0008043152,0.00001200172,0.00008453215,0.0001271243,0.000004311765,0.0000163945,0.0002350939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.182182,"threshold_uncertainty_score":0.429372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006331416393069352,"score_gpt":0.2087992576441711,"score_spread":0.2024678412511018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}