{"id":"W2171862413","doi":"10.3899/jrheum.100551","title":"Biologic DMARD May Be Insufficient to Inhibit CCL20 Pathway in Rheumatoid Arthritis","year":2010,"lang":"en","type":"letter","venue":"The Journal of Rheumatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Rheumatoid arthritis; Etanercept; Tocilizumab; Infliximab; Antirheumatic drugs; CCL20; Biologic Agents; Antirheumatic Agents; Internal medicine; Immunology; Chemokine; Tumor necrosis factor alpha; Inflammation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001264373,0.0004413718,0.001572712,0.001000547,0.000118209,0.00003280994,0.0005480052,0.00137291,0.000657931],"category_scores_gemma":[0.0009266688,0.0002773906,0.0004092757,0.0003958413,0.0002546365,0.00006809281,0.0001685589,0.008564629,0.0001587299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001520343,"about_ca_system_score_gemma":0.0004876145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003959157,"about_ca_topic_score_gemma":0.0003341073,"domain_scores_codex":[0.9965054,0.0004153761,0.001685763,0.0002980158,0.0004680092,0.0006274311],"domain_scores_gemma":[0.9969245,0.0008014496,0.001108653,0.0005953973,0.0004102002,0.0001598503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004999224,0.0003094597,0.006907341,0.0001108668,0.0001943414,0.001085959,0.001366199,0.00003050321,0.01248071,0.0001351575,0.9735139,0.003365665],"study_design_scores_gemma":[0.001504819,0.001507699,0.0003260606,0.002260552,0.00003438258,0.05963941,0.0002373093,0.0000126954,0.002975857,0.0001580308,0.9310494,0.000293761],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5810864,0.0009502801,0.00008729657,0.4151024,0.001966521,0.0003160804,0.00003924026,0.00002298819,0.000428785],"genre_scores_gemma":[0.6979359,0.003576045,0.0004453105,0.2972657,0.0003717097,0.00002010567,0.00005239842,0.00008937681,0.0002435192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1178367,"threshold_uncertainty_score":0.9999678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424279937214676,"score_gpt":0.2705765115171547,"score_spread":0.2463337121450079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}