{"id":"W2171870316","doi":"10.1093/toxsci/kfu070","title":"Localization of Cytochrome P450 and Related Enzymes in Adult Rat Testis and Downregulation by Estradiol and Bisphenol A","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"CYP17A1; Endocrinology; CYP1B1; Internal medicine; Xenoestrogen; Cytochrome P450; Estradiol benzoate; Endocrine disruptor; Biology; CYP3A; Bisphenol; Chemistry; Endocrine system; Hormone; Enzyme; Biochemistry; Metabolism; Ovariectomized rat; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008313716,0.0002600766,0.0001948371,0.0008187524,0.0001902866,0.0002092443,0.0001229164,0.0001594507,0.001865223],"category_scores_gemma":[0.0000965677,0.0001895827,0.0002571599,0.0004427905,0.0001723108,0.0001772398,0.0001165173,0.0003003983,0.0004673545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916601,"about_ca_system_score_gemma":0.0003018608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002431778,"about_ca_topic_score_gemma":0.003292754,"domain_scores_codex":[0.9998983,0.000008768649,0.000008094692,0.00002901027,0.0000306948,0.00002505378],"domain_scores_gemma":[0.9997798,0.00001085428,0.0000708083,0.00001490476,0.00006098186,0.0000626993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002277075,0.00003737014,0.002454916,0.00004489885,0.00001362406,0.00009646404,0.00003027073,0.00001636367,0.9938455,0.00004933903,0.00006471146,0.003118681],"study_design_scores_gemma":[0.0000491202,0.001038281,0.2965909,0.00001721547,0.0001079164,0.001393256,0.0002356458,0.0003529407,0.6930794,0.0001207061,0.007000924,0.00001376882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870565,0.008303938,0.002127496,0.0001209773,0.00003554016,0.00001884457,0.0009111918,0.000112927,0.001312546],"genre_scores_gemma":[0.9765328,0.007602017,0.003271218,0.00008056183,0.00004856028,0.00006806771,0.002276164,0.00003152801,0.01008918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002431778,"threshold_uncertainty_score":0.006239772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006587043531320307,"score_gpt":0.2800947334912324,"score_spread":0.2735076899599121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}