{"id":"W2171895088","doi":"10.3109/15569520903097622","title":"<i>In vitro</i>human topical bioactive drug transdermal absorption: estradiol","year":2009,"lang":"en","type":"article","venue":"Cutaneous and Ocular Toxicology","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Stratum corneum; Transdermal; Human skin; Pharmacology; Chemistry; Passive transport; Dermis; Estrogen; Drug; Absorption (acoustics); Medicine; Internal medicine; Materials science; Biochemistry; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002117738,0.0003299175,0.0004597607,0.0001489139,0.0002715492,0.00001967582,0.0002494764,0.0004769086,0.0009778023],"category_scores_gemma":[0.0000162631,0.0003407896,0.0001184415,0.000153334,0.0004116055,0.0001656709,0.00002875669,0.001027351,0.00005093658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001091491,"about_ca_system_score_gemma":0.00004322048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000125896,"about_ca_topic_score_gemma":0.0000278067,"domain_scores_codex":[0.9977508,0.0003884113,0.0004558323,0.0005672372,0.0001411663,0.0006965888],"domain_scores_gemma":[0.9992289,0.0001852081,0.00008167859,0.0002016911,0.00003709789,0.0002654391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001539826,0.001403434,0.00112825,0.00006040455,0.0001803064,0.006520807,0.00179172,0.0009707148,0.9202969,0.008482806,0.0009610378,0.05666378],"study_design_scores_gemma":[0.01377142,0.002714276,0.009021176,0.00005684846,0.0006535169,0.009951009,0.0007422931,0.007171483,0.5614305,0.02312379,0.3687716,0.002592086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879313,0.00125751,0.000524913,0.004101555,0.0007188289,0.0005612411,0.0000406419,0.0000903559,0.004773686],"genre_scores_gemma":[0.9894627,0.0004720952,0.0004400164,0.008323451,0.0003018623,0.00002864163,0.00002955264,0.00002086505,0.0009207812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3678106,"threshold_uncertainty_score":0.9999354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04035776232211811,"score_gpt":0.3800522257521817,"score_spread":0.3396944634300636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}