{"id":"W2171997865","doi":"10.1097/01.anes.0000278875.36639.2c","title":"A Conserved Tyrosine in the β2Subunit M4 Segment Is a Determinant of γ-Aminobutyric Acid Type A Receptor Sensitivity to Propofol","year":2007,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Etomidate; GABAA receptor; Propofol; Receptor; Medicine; Pharmacology; GABA receptor; Biophysics; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487498,0.0003645174,0.0002427764,0.0001455905,0.000169049,0.0002568357,0.0002524689,0.0003531969,0.001756231],"category_scores_gemma":[0.0002684501,0.0001296898,0.0003464879,0.00008229759,0.0002661384,0.0001408205,0.0002875817,0.0003563352,0.0005348088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002144231,"about_ca_system_score_gemma":0.000165089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004607089,"about_ca_topic_score_gemma":0.000333834,"domain_scores_codex":[0.9998752,0.00002586914,0.0000142263,0.00002702036,0.00003092657,0.0000268986],"domain_scores_gemma":[0.9997835,0.00004490486,0.0000933295,0.0000149549,0.00002174561,0.00004167097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002083078,0.0000152009,0.00155874,0.00001692238,0.000009826771,0.0002539821,0.00001552471,0.00006330446,0.9968923,0.00005480415,0.00001993944,0.0008910957],"study_design_scores_gemma":[0.00006186522,0.0005497502,0.04107345,0.00001590912,0.0000692013,0.002720993,0.00009630463,0.001852123,0.951893,0.00009606531,0.001555665,0.00001576693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981869,0.00016209,0.001169071,0.00003118727,0.000009838434,0.000011059,0.00005589886,0.00001669618,0.0003572529],"genre_scores_gemma":[0.9987196,0.00009100314,0.0006552576,0.00002615647,0.000003879205,0.00001338473,0.00009443699,0.00001116052,0.0003851901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756231,"threshold_uncertainty_score":0.00587517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07641589608358251,"score_gpt":0.3520633778731454,"score_spread":0.2756474817895629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}