{"id":"W2172011238","doi":"10.1111/j.1474-9726.2006.00191.x","title":"SirT1 fails to affect p53‐mediated biological functions","year":2006,"lang":"en","type":"article","venue":"Aging Cell","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute","keywords":"Biology; Sirtuin 1; Acetylation; Endogeny; Phenotype; Apoptosis; Gene; Cell biology; Genetics; Downregulation and upregulation; Cancer research; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002420172,0.0005378936,0.0005220815,0.0004064311,0.0001938352,0.0004693206,0.0004365892,0.0005252841,0.003648496],"category_scores_gemma":[0.0003014285,0.0002544922,0.0004210179,0.0002245144,0.0005135199,0.0002532235,0.0002735299,0.001045004,0.001773577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898806,"about_ca_system_score_gemma":0.0002885162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007514224,"about_ca_topic_score_gemma":0.0009196063,"domain_scores_codex":[0.9996324,0.00006180489,0.00003778684,0.00007948024,0.0001274109,0.00006119545],"domain_scores_gemma":[0.9994776,0.0001194957,0.0001195135,0.0000953879,0.00004563042,0.0001424418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006298473,0.00002943233,0.0001085207,0.00002542363,0.000007478498,0.00008380757,0.00001271499,0.00004872735,0.998415,0.0001261377,0.00007170644,0.001008081],"study_design_scores_gemma":[0.00001609342,0.0003296343,0.002297455,0.000005862916,0.00001937598,0.0004837185,0.00002490583,0.0007141476,0.991605,0.00006585183,0.004432283,0.000005559617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986846,0.003293268,0.004063292,0.0003914958,0.0001898494,0.00002721173,0.0009852223,0.0004562228,0.003747427],"genre_scores_gemma":[0.9872062,0.00136109,0.001554331,0.0001230979,0.0000279275,0.00002520427,0.001574583,0.0001272748,0.008000378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003648496,"threshold_uncertainty_score":0.01220542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415297186755074,"score_gpt":0.2588982141400973,"score_spread":0.2447452422725466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}