{"id":"W2172025902","doi":"10.3899/jrheum.111375","title":"Improved Health-related Quality of Life and Physical Function in Patients with Refractory Chronic Gout Following Treatment with Pegloticase: Evidence from Phase III Randomized Controlled Trials","year":2012,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Minimal clinically important difference; Placebo; Gout; Internal medicine; Quality of life (healthcare); Physical therapy; Randomized controlled trial; SF-36; Randomization; Visual analogue scale; Surgery; Health related quality of life; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007789635,0.0002485712,0.00603012,0.0001429272,0.0000613631,0.000005766148,0.00008056362,0.0001103335,0.00003064743],"category_scores_gemma":[0.003853326,0.0001059328,0.0003447374,0.0001408496,0.0002149132,0.0002187297,0.00001917513,0.0003790303,0.000001131749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003147252,"about_ca_system_score_gemma":0.0006558836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001609935,"about_ca_topic_score_gemma":0.00005275532,"domain_scores_codex":[0.9926996,0.00403158,0.002393495,0.0001436941,0.0004209645,0.0003107197],"domain_scores_gemma":[0.987204,0.008476686,0.003654112,0.0002708028,0.0001611951,0.0002332679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8143392,0.001637702,0.1727222,0.00006077159,0.004648438,0.000003286018,0.003858977,0.000009199263,0.001283585,0.000009611284,0.00001162083,0.001415378],"study_design_scores_gemma":[0.9582888,0.01013961,0.02559476,0.0008986747,0.003649601,0.0001222138,0.0005623694,0.0005227857,0.00006789202,0.00002520961,0.000003727585,0.0001242986],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982899,0.01348306,0.0007151967,0.0007911292,0.0002109729,0.001882206,0.000004699173,0.000009392466,0.000004420855],"genre_scores_gemma":[0.9989297,0.0007945336,0.0001330565,0.00005447775,0.00002899272,0.00002427153,0.000006619812,0.00001939308,0.000008900322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1471275,"threshold_uncertainty_score":0.4613069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03413084113614858,"score_gpt":0.3331730660050705,"score_spread":0.299042224868922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}