{"id":"W2172068213","doi":"10.1128/mcb.22.12.3970-3980.2002","title":"Protein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; Leibniz-Gemeinschaft; Deutsche Forschungsgemeinschaft","keywords":"Degranulation; Biology; Regulator; Mast cell; Cell biology; Antigen; Protein kinase A; Kinase; Molecular biology; Biochemistry; Immunology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001057341,0.0002048867,0.0003298032,0.0001134215,0.00010692,0.000006468427,0.0001200931,0.0003339127,0.001386895],"category_scores_gemma":[0.00001651586,0.0001843558,0.00010432,0.0001287059,0.0002453433,0.00002531476,0.00006539826,0.0001636282,0.00009954503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001034464,"about_ca_system_score_gemma":0.00001208398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000127048,"about_ca_topic_score_gemma":0.000005691464,"domain_scores_codex":[0.9988056,0.000191324,0.0003016598,0.0003753542,0.000028483,0.0002975161],"domain_scores_gemma":[0.9994304,0.00002047137,0.0001594075,0.0002859466,0.00006888245,0.00003494301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004392378,0.0001277406,0.0004962407,0.00003901486,0.00005170255,0.00001248993,0.0004503413,4.249563e-7,0.9937474,0.001321867,0.0001015998,0.003607277],"study_design_scores_gemma":[0.001180875,0.000389565,0.0003253878,0.00001559698,0.00002480101,0.00001030514,0.00007843265,0.00005061976,0.9885324,0.0003697332,0.008825026,0.0001972391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890219,0.006024112,0.001357614,0.0001522098,0.0001153351,0.0003509966,0.00003523954,0.00002355511,0.002919032],"genre_scores_gemma":[0.9972123,0.00004605808,0.0002337108,0.0001050936,0.00001301077,0.00001665314,0.00008460054,0.00001806085,0.00227054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008723426,"threshold_uncertainty_score":0.999526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009719750514536885,"score_gpt":0.1933286376842491,"score_spread":0.1836088871697122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}