{"id":"W2172112777","doi":"10.1093/jhered/esn073","title":"Evolution and Differentiation of the Prion Protein Gene (PRNP) among Species","year":2008,"lang":"en","type":"article","venue":"Journal of Heredity","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hebei University; Iowa State University; University of Calgary","keywords":"Biology; PRNP; Phylogenetic tree; Nonsynonymous substitution; Genetics; Gene; Phylogenetics; Nucleotide diversity; Evolutionary biology; Genotype; Genome; Haplotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003881481,0.0001595788,0.0002628306,0.001764908,0.0004788077,0.0004001574,0.000196431,0.0002874523,0.0003716925],"category_scores_gemma":[0.000699056,0.000178743,0.0002292996,0.0007529925,0.0003289394,0.0003872494,0.0003234673,0.0002529964,0.0001535921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762211,"about_ca_system_score_gemma":0.0001009865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005997202,"about_ca_topic_score_gemma":0.0008717356,"domain_scores_codex":[0.999777,0.00005044223,0.00001652227,0.00007976954,0.00003911219,0.00003708175],"domain_scores_gemma":[0.9994541,0.0001800084,0.0001387224,0.00003302614,0.0001046881,0.0000894293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007013126,0.00009936971,0.5595238,0.0001180274,0.0001716542,0.0007218611,0.002400656,0.0007979423,0.4124188,0.0004072515,0.00008598428,0.02255338],"study_design_scores_gemma":[0.000009976736,0.0001720971,0.992863,0.00001709972,0.00004448894,0.001133949,0.0004633434,0.001838391,0.002607042,0.0003003005,0.0005357981,0.00001445789],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996468,0.0001063899,0.0001190629,0.000002949256,5.666951e-7,0.000001497111,0.00002349434,0.000001306298,0.00009794519],"genre_scores_gemma":[0.999249,0.00009198939,0.0004235817,0.00000606679,0.000001922606,0.000002953601,0.0001648423,0.000002665942,0.00005695981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764908,"threshold_uncertainty_score":0.002052724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030219084455105,"score_gpt":0.2072375354875551,"score_spread":0.1969353446430041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}