{"id":"W2172112777","doi":"10.1093/jhered/esn073","title":"Evolution and Differentiation of the Prion Protein Gene (PRNP) among Species","year":2008,"lang":"en","type":"article","venue":"Journal of Heredity","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hebei University; Iowa State University; University of Calgary","keywords":"Biology; PRNP; Phylogenetic tree; Nonsynonymous substitution; Genetics; Gene; Phylogenetics; Nucleotide diversity; Evolutionary biology; Genotype; Genome; Haplotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262845,0.00005207831,0.00008276062,0.00001802799,0.00007281563,0.00000543549,0.00008479247,0.00005404361,0.00001131379],"category_scores_gemma":[0.0000922262,0.0000350064,0.00008266173,0.00003544982,0.00007319369,0.00000751561,0.0000510177,0.00006622329,1.237024e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000140566,"about_ca_system_score_gemma":0.00005270032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008223047,"about_ca_topic_score_gemma":0.000006326032,"domain_scores_codex":[0.999493,0.00005711493,0.0001841846,0.00006137437,0.000142508,0.00006181417],"domain_scores_gemma":[0.9994741,0.000003540988,0.0002837752,0.00009807407,0.0001042642,0.00003623399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006627931,0.0000370425,0.1224192,0.00001671092,0.00002153199,0.00000138279,0.00002430501,0.00002066179,0.8761497,0.00001617283,0.0003445284,0.0008824819],"study_design_scores_gemma":[0.000238851,0.00009427941,0.6675732,0.00002549117,0.00001181915,0.00002892518,0.00001561754,0.00002446747,0.3313232,0.0001296837,0.0005001753,0.00003427636],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955671,0.002906742,0.001205974,0.00006768952,0.0001261254,0.00009987762,0.000005164359,0.000001037854,0.0000203153],"genre_scores_gemma":[0.9988082,0.0005922359,0.0001930196,0.000007555685,0.0003316119,0.000001144655,0.000001822814,0.00000382627,0.000060551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.545154,"threshold_uncertainty_score":0.142752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030219084455105,"score_gpt":0.2072375354875551,"score_spread":0.1969353446430041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}