{"id":"W2172122039","doi":"10.1200/jco.2008.18.3087","title":"Single-Agent Bortezomib in Previously Untreated Multiple Myeloma: Efficacy, Characterization of Peripheral Neuropathy, and Molecular Correlations With Response and Neuropathy","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; National Eye Institute; Takeda Oncology; Celgene","keywords":"Medicine; Bortezomib; Multiple myeloma; Polyneuropathy; Peripheral neuropathy; Internal medicine; Surgery; Oncology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006030297,0.0002874169,0.000776243,0.0003218465,0.0001952673,0.0001853607,0.00018994,0.0002479905,0.0005589326],"category_scores_gemma":[0.0007314748,0.0001080359,0.0002317377,0.0002840222,0.000223505,0.0002081622,0.0001411829,0.0002575601,0.0001119007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532484,"about_ca_system_score_gemma":0.0002238375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006324755,"about_ca_topic_score_gemma":0.001779003,"domain_scores_codex":[0.9997373,0.00008377832,0.00002655717,0.00005861478,0.00006122535,0.00003243264],"domain_scores_gemma":[0.9995956,0.0001114608,0.0001445003,0.00001926461,0.00003026254,0.00009888763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02693871,0.001531423,0.7108043,0.0006154394,0.0006484793,0.0009819506,0.000278348,0.002653934,0.1195208,0.00006282883,0.0004127884,0.1355509],"study_design_scores_gemma":[0.001489025,0.0341154,0.9415469,0.00004682165,0.000306659,0.003625287,0.0001125537,0.002539643,0.01504953,0.000109881,0.001040143,0.00001799975],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976545,0.002012449,0.00009730689,0.000025049,0.000003657501,0.00001861351,0.00004825266,0.000006639909,0.0001335308],"genre_scores_gemma":[0.9990693,0.0003865213,0.0002473408,0.0000385052,0.00001295263,0.00001769715,0.0001347815,0.000001545331,0.00009150643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000776243,"threshold_uncertainty_score":0.003288567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05753808831090486,"score_gpt":0.3811943247090732,"score_spread":0.3236562363981684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}