{"id":"W2172142392","doi":"10.1016/j.cellsig.2010.04.010","title":"A functional RNAi screen identifies hexokinase 1 as a modifier of type II apoptosis","year":2010,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"RNA interference; Apoptosis; Hexokinase; Cell biology; Biology; Computational biology; Chemistry; Biochemistry; Gene; Enzyme; Glycolysis; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304813,0.0006436411,0.0004230231,0.0005412122,0.0002615604,0.0004598084,0.0004354438,0.0003741664,0.00312972],"category_scores_gemma":[0.0001719968,0.0003184061,0.0003448734,0.0003000546,0.0002943885,0.000184863,0.0002742428,0.0007206594,0.0006861525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006007599,"about_ca_system_score_gemma":0.0002438366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001062004,"about_ca_topic_score_gemma":0.001893629,"domain_scores_codex":[0.9998305,0.00001618769,0.00001684895,0.00004359994,0.0000591304,0.00003379292],"domain_scores_gemma":[0.9998162,0.00004962607,0.00006148354,0.00001918045,0.00001374787,0.00003976683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005538907,0.000009590899,0.0001029362,0.00001352611,0.000005129518,0.00006833326,0.000003031832,0.00004465419,0.9990251,0.00008464944,0.00004143512,0.0005461932],"study_design_scores_gemma":[0.00001669826,0.00007271132,0.002627376,0.000003012364,0.00003432891,0.0002768126,0.00001008071,0.0006798169,0.9951124,0.00004410926,0.001117284,0.000005367395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798329,0.001409341,0.01080954,0.0003241919,0.0001535589,0.0001070768,0.002571376,0.0006210331,0.004170859],"genre_scores_gemma":[0.9857717,0.0007800207,0.003988729,0.0001353249,0.00001458445,0.0000385298,0.001608029,0.0001152761,0.007547739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00312972,"threshold_uncertainty_score":0.01046997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288629107047497,"score_gpt":0.221668966717431,"score_spread":0.208782675646956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}