{"id":"W2172177787","doi":"10.1110/ps.0302403","title":"Crystal complexes of a predicted S‐adenosylmethionine‐dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain","year":2003,"lang":"en","type":"article","venue":"Protein Science","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; National Institute on Aging; Northwestern University; National Science Foundation; National Institutes of Health; DuPont; U.S. Department of Energy","keywords":"Thermotoga maritima; Methyltransferase; Biology; Binding site; Protein structure; Transferase; Operon; Structural genomics; Sequence alignment; Stereochemistry; Methylation; Biochemistry; Crystallography; Peptide sequence; Enzyme; Chemistry; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000242848,0.0006519386,0.0007402879,0.0002330463,0.0005733919,0.0008777722,0.001022953,0.0008452224,0.002849377],"category_scores_gemma":[0.0004217048,0.0003993067,0.0002608879,0.0005220927,0.0002946098,0.0003442626,0.0003172071,0.001835593,0.0006549291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001180599,"about_ca_system_score_gemma":0.0005905717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005892962,"about_ca_topic_score_gemma":0.007108729,"domain_scores_codex":[0.9997326,0.00001918924,0.000009560456,0.00006453576,0.0001127837,0.00006146691],"domain_scores_gemma":[0.9998077,0.00003878163,0.00003524755,0.000009751908,0.00003887208,0.00006968913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003917535,0.001252595,0.0226606,0.001096267,0.0006770963,0.002534076,0.001516957,0.004400497,0.881501,0.003149768,0.03921346,0.03808027],"study_design_scores_gemma":[0.003541795,0.002554738,0.1803904,0.0003501225,0.0008557115,0.009829964,0.002981112,0.1185665,0.5019291,0.002368409,0.1763189,0.0003131306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860613,0.003576626,0.001575456,0.0009893929,0.000180879,0.00004048138,0.001938717,0.0005083285,0.005128736],"genre_scores_gemma":[0.9699514,0.001830895,0.008116478,0.0004085712,0.00003986553,0.00009161995,0.01125583,0.0001086076,0.008196645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005892962,"threshold_uncertainty_score":0.01171732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069952376860787,"score_gpt":0.266806757422325,"score_spread":0.2461072336537171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}