{"id":"W2172191429","doi":"10.1074/jbc.m109.053363","title":"Crystal Structure of a Mammalian CTP: Phosphocholine Cytidylyltransferase Catalytic Domain Reveals Novel Active Site Residues within a Highly Conserved Nucleotidyltransferase Fold","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Basic Energy Sciences; Canadian Institutes of Health Research; Office of Science; Michael Smith Health Research BC; U.S. Department of Energy","keywords":"Phosphocholine; Biochemistry; Active site; Binding site; C2 domain; Transferase; Biology; Chemistry; Phosphatidylcholine; Phospholipid; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104942,0.0004096239,0.0002751933,0.00006588946,0.0001838007,0.0003821223,0.0003115432,0.0004395102,0.0008923631],"category_scores_gemma":[0.0001565135,0.0001295069,0.0001702707,0.0002002585,0.0001788118,0.0001658034,0.0001370311,0.0007256095,0.0004819889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006423123,"about_ca_system_score_gemma":0.0003706835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001983701,"about_ca_topic_score_gemma":0.002042668,"domain_scores_codex":[0.9999454,0.000005579869,0.000002789364,0.00001310365,0.00002341025,0.000009856783],"domain_scores_gemma":[0.9999235,0.000009405184,0.00001543126,0.000003098541,0.00001032374,0.00003829986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006168416,0.0001434275,0.002561378,0.0001368639,0.0000345867,0.000822692,0.0001140918,0.001575841,0.9870658,0.0004699076,0.001301569,0.005157091],"study_design_scores_gemma":[0.0007515255,0.001148973,0.1033659,0.00010753,0.0002335634,0.009119182,0.0004773849,0.04496057,0.7940657,0.001183199,0.04447922,0.0001073917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994018,0.001444037,0.00180311,0.0001872372,0.00003215021,0.0000241608,0.0007293785,0.0001160047,0.001646017],"genre_scores_gemma":[0.9857441,0.001064053,0.005034131,0.0001663023,0.00001658665,0.00002892573,0.004978457,0.00004288118,0.00292469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001983701,"threshold_uncertainty_score":0.004660368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01510368870042782,"score_gpt":0.2609294694552122,"score_spread":0.2458257807547843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}