{"id":"W2172202106","doi":"10.1016/j.aquatox.2010.02.013","title":"Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa","year":2010,"lang":"en","type":"article","venue":"Aquatic Toxicology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":331,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Western Economic Diversification Canada; National Institute of Environmental Research; University of Hong Kong; National Research Foundation of Korea; Canada Research Chairs; State Key Laboratory in Marine Pollution; University of Saskatchewan; City University of Hong Kong","keywords":"Oryzias; Daphnia magna; Biology; Vitellogenin; Cladocera; Hatching; Reproduction; EC50; Ibuprofen; Aquatic toxicology; Toxicology; Toxicity; Testosterone (patch); Chronic toxicity; Methyltestosterone; Endocrinology; Internal medicine; Zoology; Animal science; Ecology; Pharmacology; Crustacean; Fish <Actinopterygii>; Fishery; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008568256,0.0003015038,0.0002297449,0.0003913036,0.0003763418,0.0003115706,0.0001571266,0.0004090049,0.001012627],"category_scores_gemma":[0.0001978608,0.0002786225,0.0003179325,0.0002691284,0.0003786081,0.0003233511,0.0002720511,0.0004232787,0.0001533966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004787865,"about_ca_system_score_gemma":0.0002524925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00954526,"about_ca_topic_score_gemma":0.01598966,"domain_scores_codex":[0.9998987,0.00001123467,0.000009237883,0.00003303598,0.00001461928,0.00003305088],"domain_scores_gemma":[0.999844,0.0000183028,0.00005096111,0.00001207692,0.00002833288,0.00004620985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005096397,0.0003337003,0.04906982,0.0000742805,0.00009811528,0.0004600393,0.000370681,0.0001551818,0.9401039,0.00005265197,0.0001113566,0.004074007],"study_design_scores_gemma":[0.00007032165,0.004675459,0.7583988,0.00001788213,0.0003267802,0.001111209,0.001372943,0.0006933564,0.2320554,0.0001380247,0.001100469,0.00003935883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996518,0.0001190691,0.00004057852,0.00001289186,0.000002902261,0.000002186511,0.00008701597,0.000001875267,0.00008177793],"genre_scores_gemma":[0.9985622,0.0001993057,0.00007233962,0.00002990947,0.000002783994,0.00000935867,0.000188482,0.0000018601,0.0009338389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00954526,"threshold_uncertainty_score":0.01897943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00880904514078471,"score_gpt":0.2678590257332301,"score_spread":0.2590499805924453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}