{"id":"W2172206033","doi":"10.1080/10408440591007421","title":"Mode of Action: Disruption of Brain Cell Replication, Second Messenger, and Neurotransmitter Systems During Development Leading to Cognitive Dysfunction—Developmental Neurotoxicity of Nicotine","year":2005,"lang":"en","type":"review","venue":"Critical Reviews in Toxicology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; U.S. Environmental Protection Agency","keywords":"Nicotine; Neurotransmitter; Serotonergic; Nicotinic agonist; Neuroscience; Dopaminergic; Cholinergic; Neurotoxicity; Neurotransmitter systems; Mode of action; Animal studies; Biology; Pharmacology; Receptor; Endocrinology; Medicine; Internal medicine; Central nervous system; Dopamine; Serotonin; Toxicity; Toxicology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003597291,0.001062349,0.00121572,0.001279689,0.0003007273,0.0008237588,0.001349111,0.001278699,0.00359773],"category_scores_gemma":[0.0002612605,0.0002320191,0.0003266089,0.001179353,0.0007569394,0.00146904,0.0004606406,0.001187248,0.003683911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008468448,"about_ca_system_score_gemma":0.0007443169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008572686,"about_ca_topic_score_gemma":0.001185743,"domain_scores_codex":[0.9998752,0.00001997747,0.00001373593,0.00003064285,0.00004856259,0.00001199401],"domain_scores_gemma":[0.999898,0.00002893942,0.00001470639,0.000005887473,0.00003944655,0.00001310383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001219194,0.0000976917,0.0002359041,0.01361694,0.00006531065,0.0006298095,0.00009501377,0.000457559,0.01860391,0.01064936,0.04510967,0.9103169],"study_design_scores_gemma":[0.0000193116,0.00009811055,0.0007316158,0.001151915,0.00003975458,0.002772255,0.00005704315,0.00007608427,0.002730151,0.002754652,0.9895516,0.00001743247],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000276827,0.9942215,0.000677906,0.0003420922,0.0005008225,0.00001363503,0.00002470834,0.00002235384,0.003920138],"genre_scores_gemma":[0.001666572,0.9945215,0.0004093127,0.000241853,0.0002149176,0.00001661971,0.00002699734,0.000003239547,0.002899012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00359773,"threshold_uncertainty_score":0.01203561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06163064743544713,"score_gpt":0.40116867697569,"score_spread":0.3395380295402429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}