{"id":"W2172212187","doi":"10.1128/jvi.01349-08","title":"Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reverse transcriptase; Biology; Mutation; Virology; DNA; Virus; RNA-Directed DNA Polymerase; Nucleotide; Human immunodeficiency virus (HIV); DNA sequencing; Molecular biology; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005812065,0.00007821539,0.0002364464,0.000144366,0.0001594538,0.000001966798,0.0002239043,0.00013139,0.0004043598],"category_scores_gemma":[0.00009010441,0.00004480558,0.0001278325,0.0001555453,0.00027475,0.00006782808,0.00002279022,0.0002269472,0.00001396164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000288818,"about_ca_system_score_gemma":0.0001867755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001792828,"about_ca_topic_score_gemma":0.00006678707,"domain_scores_codex":[0.9988041,0.0004166778,0.000451059,0.00008714395,0.00006041921,0.0001805842],"domain_scores_gemma":[0.9990972,0.000208461,0.0003503995,0.0001771268,0.0001561561,0.00001066905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004083479,0.0003428597,0.00163105,0.00001337161,0.0001790746,0.0000161603,0.001223071,0.00003340211,0.9908633,0.0001769853,0.001094798,0.0003425109],"study_design_scores_gemma":[0.007149054,0.005017268,0.4075498,0.00005558232,0.0001947597,0.0006284396,0.0002140002,0.00001480625,0.5757428,0.0009493135,0.002395566,0.00008860548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965492,0.0021823,0.0001219477,0.0004197254,0.0003207804,0.0002379403,0.00009753185,0.000001556463,0.00006898027],"genre_scores_gemma":[0.9992166,0.0003790021,0.00003768619,0.00005864022,0.00001200505,0.000004522105,0.00001404918,0.000005645077,0.0002718911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4151204,"threshold_uncertainty_score":0.4427457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042825764322844,"score_gpt":0.3028280114865675,"score_spread":0.2600022471637234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}