{"id":"W2172212187","doi":"10.1128/jvi.01349-08","title":"Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reverse transcriptase; Biology; Mutation; Virology; DNA; Virus; RNA-Directed DNA Polymerase; Nucleotide; Human immunodeficiency virus (HIV); DNA sequencing; Molecular biology; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004852835,0.0003141527,0.0002569165,0.0002801442,0.0002619687,0.0008110258,0.0003304402,0.0005684946,0.00121077],"category_scores_gemma":[0.001201597,0.0003587387,0.0004221747,0.0002144135,0.0002925662,0.0003333055,0.0002045684,0.0005020188,0.0007655958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002276577,"about_ca_system_score_gemma":0.0002861139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006043818,"about_ca_topic_score_gemma":0.0006053321,"domain_scores_codex":[0.9995033,0.00009114407,0.00005661077,0.0001016789,0.0001643622,0.0000830188],"domain_scores_gemma":[0.9992354,0.0001852146,0.0002737835,0.000146031,0.00007687677,0.0000827577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002508568,0.00005153914,0.01002718,0.00006512792,0.00002142953,0.0005376704,0.000101012,0.0003913133,0.9804349,0.0005156828,0.00006772852,0.007535672],"study_design_scores_gemma":[0.00004255188,0.001018559,0.05529682,0.00003390721,0.00009509738,0.009211874,0.0001455213,0.006231359,0.9243573,0.0007383177,0.002784355,0.00004445722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923809,0.0009287573,0.004842951,0.00004354401,0.00001898028,0.00003250881,0.0000764938,0.00009441247,0.001581425],"genre_scores_gemma":[0.9974215,0.0002563064,0.001890633,0.00003458626,0.00001046487,0.00001037565,0.00008996216,0.0000267634,0.000259412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00121077,"threshold_uncertainty_score":0.004050434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042825764322844,"score_gpt":0.3028280114865675,"score_spread":0.2600022471637234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}