{"id":"W2172231359","doi":"10.1158/1535-7163.mct-07-2150","title":"Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Protein kinase B; Biology; Kinase; Geldanamycin; Protein kinase A; p38 mitogen-activated protein kinases; PI3K/AKT/mTOR pathway; Synthetic lethality; Signal transduction; Programmed cell death; Molecular biology; Cell biology; Apoptosis; Cancer research; Heat shock protein; Biochemistry; Hsp90; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008278836,0.0004628581,0.0002270001,0.0001308791,0.0001316214,0.0001656171,0.0001036669,0.0001422138,0.0005001213],"category_scores_gemma":[0.00004261145,0.0001059209,0.0002969877,0.0001285616,0.0001287783,0.0001319617,0.0001306105,0.0003486162,0.0001709631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002918939,"about_ca_system_score_gemma":0.0002498509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000953073,"about_ca_topic_score_gemma":0.001616168,"domain_scores_codex":[0.9999214,0.00001373322,0.000006608228,0.000009953321,0.00001927148,0.00002903522],"domain_scores_gemma":[0.9999733,0.000003128982,0.000007285724,0.000002955411,0.000005396578,0.000007984857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001205957,0.00003814948,0.0002563651,0.00003959276,0.000007659686,0.00004087053,0.00001932946,0.00007850036,0.9985825,0.00006690611,0.0000232218,0.0007263583],"study_design_scores_gemma":[0.00001048694,0.000405629,0.004078408,0.000003101529,0.00001605391,0.0001460879,0.00003136379,0.0004993087,0.9941251,0.00002732611,0.0006546181,0.000002497024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969016,0.001550153,0.0007473837,0.00003781985,0.00001220057,0.00001487289,0.0002370217,0.00002316604,0.0004758682],"genre_scores_gemma":[0.9967965,0.001143265,0.0007417144,0.00002063005,0.000002938194,0.00003060878,0.0005102397,0.000004516677,0.0007495787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000953073,"threshold_uncertainty_score":0.002117872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288710974497734,"score_gpt":0.2451297713880397,"score_spread":0.2322426616430624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}