{"id":"W2172231359","doi":"10.1158/1535-7163.mct-07-2150","title":"Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Protein kinase B; Biology; Kinase; Geldanamycin; Protein kinase A; p38 mitogen-activated protein kinases; PI3K/AKT/mTOR pathway; Synthetic lethality; Signal transduction; Programmed cell death; Molecular biology; Cell biology; Apoptosis; Cancer research; Heat shock protein; Biochemistry; Hsp90; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181539,0.0001700353,0.0001744418,0.00006285363,0.00007598322,0.00001294424,0.0001215321,0.0001737455,0.00002217483],"category_scores_gemma":[0.000005992686,0.0001783228,0.00006471447,0.0001411833,0.000129798,0.000007186482,0.00005068989,0.0001020357,7.114666e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003087954,"about_ca_system_score_gemma":0.00006210021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005436282,"about_ca_topic_score_gemma":0.00003406773,"domain_scores_codex":[0.9989365,0.00008813789,0.0002886016,0.0003032338,0.000185237,0.0001982977],"domain_scores_gemma":[0.9994755,0.000005656434,0.0001365682,0.0002521395,0.00007584955,0.00005430304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005917385,0.00006690707,0.0009007616,0.00001865753,0.00003650488,0.000003023578,0.00009902723,0.0001965058,0.9967303,0.00006871125,0.0001480834,0.001672355],"study_design_scores_gemma":[0.0006823652,0.0002571198,0.0004808601,0.00002743532,0.00001224907,0.000004247484,0.00001970419,0.0001541507,0.988188,0.00009637063,0.009879931,0.0001975597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936851,0.003114049,0.002607999,0.00009585783,0.00006326247,0.0002294851,0.00002994298,0.00001135457,0.0001629588],"genre_scores_gemma":[0.9984788,0.0003292481,0.0002676808,0.0005162073,0.00005005387,0.00002448035,0.00004029424,0.00002951174,0.0002637233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009731848,"threshold_uncertainty_score":0.7271793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288710974497734,"score_gpt":0.2451297713880397,"score_spread":0.2322426616430624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}