{"id":"W2172250423","doi":"10.1515/bc.2003.094","title":"Family C1 Cysteine Proteases: Biological Diversity or Redundancy?","year":2003,"lang":"en","type":"review","venue":"Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Proteases; Cathepsin; Protease; Biology; Cathepsin C; Biochemistry; Cysteine; Deubiquitinating enzyme; Cathepsin B; Enzyme; Functional diversity; Phenotype; Computational biology; Cell biology; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005111334,0.0009467138,0.00122151,0.001548571,0.0002321479,0.0009229212,0.001141567,0.001024701,0.002175911],"category_scores_gemma":[0.0004386973,0.0001757699,0.0001890258,0.001821715,0.0005729942,0.001441968,0.0004021688,0.001136658,0.002488215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007935499,"about_ca_system_score_gemma":0.0008952475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000987424,"about_ca_topic_score_gemma":0.001753334,"domain_scores_codex":[0.999848,0.00001878132,0.00001724018,0.00003703002,0.0000588501,0.00002003458],"domain_scores_gemma":[0.9997965,0.00005468639,0.00003934197,0.000009036425,0.00006738765,0.00003318919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001240047,0.00002839878,0.0003526235,0.008043074,0.00008170208,0.0006398758,0.00006352118,0.0002063463,0.006819724,0.004162295,0.0250608,0.9544176],"study_design_scores_gemma":[0.00003055321,0.00007526638,0.001235493,0.001189191,0.00007923668,0.006133339,0.00008361682,0.00009330025,0.002004971,0.002924284,0.9861308,0.00002008081],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003059647,0.9976284,0.0002885968,0.0003476215,0.0001596891,0.000003564979,0.00001491997,0.000008956879,0.001242312],"genre_scores_gemma":[0.002272024,0.995153,0.0004229457,0.0002680381,0.0001992249,0.000007340837,0.00004858135,0.000001971838,0.001626938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002175911,"threshold_uncertainty_score":0.007279098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1114677137330176,"score_gpt":0.3121606391729173,"score_spread":0.2006929254398997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}