{"id":"W2172250423","doi":"10.1515/bc.2003.094","title":"Family C1 Cysteine Proteases: Biological Diversity or Redundancy?","year":2003,"lang":"en","type":"review","venue":"Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Proteases; Cathepsin; Protease; Biology; Cathepsin C; Biochemistry; Cysteine; Deubiquitinating enzyme; Cathepsin B; Enzyme; Functional diversity; Phenotype; Computational biology; Cell biology; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003898867,0.0009627513,0.001626572,0.0000315827,0.0003338592,0.00004595753,0.001018665,0.002691348,0.0003831233],"category_scores_gemma":[0.000538221,0.0005881324,0.0009881291,0.000236978,0.0003275518,0.000004597347,0.00155437,0.0006382584,0.0001150177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009290975,"about_ca_system_score_gemma":0.0003792275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007096663,"about_ca_topic_score_gemma":3.198656e-7,"domain_scores_codex":[0.9963464,0.0003272193,0.00075427,0.001563575,0.0002452265,0.0007633815],"domain_scores_gemma":[0.9980835,0.00004740713,0.0004496373,0.0009411009,0.0001026579,0.0003756414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001181316,0.002204807,0.0001174255,0.02034214,0.001707096,0.0009850559,0.00001506209,5.063998e-7,0.5384375,0.0001566237,0.03385791,0.4009945],"study_design_scores_gemma":[0.0003815114,0.0007321361,0.000001058346,0.001090856,0.000142747,0.0002072424,0.00001276499,1.713027e-7,0.02075234,0.0000747365,0.9756638,0.0009406352],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002282897,0.9921779,0.0001091025,0.000006772393,0.000242728,0.001228228,0.0004251534,0.0001017971,0.00342543],"genre_scores_gemma":[0.0009891543,0.9918746,0.0004859665,0.0002239106,0.001065701,0.0003947264,0.001925341,0.00005420843,0.002986356],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9418059,"threshold_uncertainty_score":0.999657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1114677137330176,"score_gpt":0.3121606391729173,"score_spread":0.2006929254398997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}