{"id":"W2172253011","doi":"10.1002/gene.20001","title":"Unexpected embryonic stem (ES) cell mutations represent a concern in gene targeting: Lessons from “fierce” mice","year":2004,"lang":"en","type":"article","venue":"genesis","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"National Institute of Mental Health","keywords":"Biology; Phenotype; Gene targeting; Embryonic stem cell; Genetics; Gene; Gene knockout; Mutation; Gene knockin; Knockout mouse","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741663,0.0002053195,0.0002116192,0.0001003421,0.0001112888,0.00003835967,0.0003805051,0.0002086135,0.00004666544],"category_scores_gemma":[0.00004908138,0.0002192685,0.0001191508,0.0002920218,0.00007873362,0.000005933517,0.0002362351,0.0001364676,0.0001179662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001039778,"about_ca_system_score_gemma":0.0002850149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194836,"about_ca_topic_score_gemma":0.0004027382,"domain_scores_codex":[0.9980761,0.0001558753,0.0003063657,0.0007159002,0.0002691309,0.0004766147],"domain_scores_gemma":[0.9990578,0.00003455045,0.00009560238,0.0005504002,0.0001120901,0.0001496044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005517529,0.0001323592,0.002388768,0.00001558174,0.00004389487,0.00004544836,0.0002213486,0.005280661,0.9910234,0.000009552014,0.0005067717,0.0002770918],"study_design_scores_gemma":[0.001339192,0.00006888141,0.007340573,0.00001490585,0.00002236199,0.000005685908,0.0005709804,0.0001540248,0.9871392,0.00005889006,0.003018676,0.0002666658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922521,0.004640428,0.001287389,0.000810739,0.0001172415,0.0003231379,0.0001153308,0.00002849784,0.0004251913],"genre_scores_gemma":[0.9956068,0.000656426,0.001544889,0.00009304571,0.0001700795,0.0000818399,0.0005186946,0.00004405644,0.001284133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005126636,"threshold_uncertainty_score":0.8941511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688755641579154,"score_gpt":0.2878321851573724,"score_spread":0.2609446287415808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}