{"id":"W2172260616","doi":"10.1083/jcb.200908086","title":"Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling","year":2010,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":907,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Hospital for Sick Children","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Pinocytosis; Amiloride; Biology; Cell biology; Endocytosis; Cytosol; CDC42; Nigericin; Biophysics; Phosphatidylinositol; Biochemistry; RAC1; Staurosporine; Phosphorylation; Signal transduction; Protein kinase C; Receptor; Chemistry; Sodium; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001185599,0.0002937538,0.0003091369,0.00016639,0.0001670872,0.0003837896,0.0003126262,0.0003524957,0.001075456],"category_scores_gemma":[0.0001152882,0.0001241947,0.000198149,0.0001198312,0.0002466915,0.0002300994,0.0002264331,0.000854758,0.0003078575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389138,"about_ca_system_score_gemma":0.0003739644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004604744,"about_ca_topic_score_gemma":0.000777386,"domain_scores_codex":[0.9998738,0.00001724283,0.00001539833,0.00002191798,0.00003592699,0.00003586636],"domain_scores_gemma":[0.9999245,0.00001667024,0.00001489609,0.000008543842,0.000009207901,0.00002613199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049333,0.00002239702,0.00004830744,0.00001754927,0.000002887501,0.00002688286,0.000006091878,0.00001753931,0.9988548,0.00009773095,0.00002568365,0.000775281],"study_design_scores_gemma":[0.00002033534,0.0002221732,0.002134683,0.000002389016,0.000007879096,0.0001166083,0.00001360182,0.0004467181,0.9954365,0.00003965857,0.001556878,0.000002609873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920141,0.002113212,0.00235624,0.0002090793,0.00004962262,0.00004065164,0.0002757127,0.0001202649,0.002821126],"genre_scores_gemma":[0.9927034,0.001705752,0.002736892,0.00007691314,0.0000267653,0.00006553125,0.000357656,0.00001804715,0.002309054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075456,"threshold_uncertainty_score":0.003597736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005133074394693846,"score_gpt":0.2057888638431112,"score_spread":0.2006557894484173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}