{"id":"W2172260616","doi":"10.1083/jcb.200908086","title":"Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling","year":2010,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":907,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Hospital for Sick Children","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Pinocytosis; Amiloride; Biology; Cell biology; Endocytosis; Cytosol; CDC42; Nigericin; Biophysics; Phosphatidylinositol; Biochemistry; RAC1; Staurosporine; Phosphorylation; Signal transduction; Protein kinase C; Receptor; Chemistry; Sodium; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004893492,0.0001066056,0.0001488921,0.00002994367,0.00009155613,0.00001351093,0.0001101559,0.0001342313,0.00001264957],"category_scores_gemma":[0.00002208249,0.00007530465,0.00005037909,0.00003023656,0.0001208468,0.000005254286,0.00004434142,0.0002316658,5.148762e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002727229,"about_ca_system_score_gemma":0.00002053825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001202734,"about_ca_topic_score_gemma":0.00001881052,"domain_scores_codex":[0.9993702,0.00005115877,0.0002519463,0.0001139443,0.00004877112,0.0001640161],"domain_scores_gemma":[0.9995623,0.00002856182,0.0001932065,0.00009812885,0.00005488973,0.00006293658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000124437,0.00001515193,0.002427137,0.0000181726,0.0000244562,0.000001824554,0.00009457113,0.000004277661,0.9958588,0.000004123061,0.00000873368,0.001418264],"study_design_scores_gemma":[0.0004775209,0.0002219348,0.0004609183,0.00001059587,0.00004671779,0.0001123831,0.00005090002,0.00001544545,0.9916542,0.00007030338,0.006786154,0.00009290643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936987,0.003194239,0.002638689,0.00007457755,0.0001936614,0.00006373216,0.000004343377,0.000002542062,0.0001295362],"genre_scores_gemma":[0.9973512,0.0020441,0.0001800363,0.00007417714,0.0002203616,6.391999e-7,0.00004084467,0.00001125309,0.00007740799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00677742,"threshold_uncertainty_score":0.3070835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005133074394693846,"score_gpt":0.2057888638431112,"score_spread":0.2006557894484173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}