{"id":"W2172364943","doi":"10.1161/atvbaha.115.305619","title":"Implications of α <sub>v</sub> β <sub>3</sub> Integrin Signaling in the Regulation of Ca <sup>2+</sup> Waves and Myogenic Tone in Cerebral Arteries","year":2015,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Phospholipase C; Myogenic contraction; Phosphorylation; Myosin-light-chain phosphatase; Cell biology; Myosin light-chain kinase; Signal transduction; Integrin; Biology; Protein kinase C; Chemistry; Internal medicine; Endocrinology; Receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009105771,0.0002198886,0.0006264523,0.0003229009,0.00006307562,0.00002276164,0.0001533722,0.0002119568,0.00001268721],"category_scores_gemma":[0.0001760742,0.0001669332,0.0001332577,0.000445667,0.0004920213,0.00009931309,0.0001494788,0.0002363962,0.000004056971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005594676,"about_ca_system_score_gemma":0.00008450685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001506819,"about_ca_topic_score_gemma":0.0002052012,"domain_scores_codex":[0.9979337,0.0004288959,0.0006379735,0.0004338927,0.0002189567,0.0003465346],"domain_scores_gemma":[0.9988719,0.0001858173,0.0001782347,0.0004821809,0.0001586297,0.0001232399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000228643,0.0001823583,0.09654249,0.00007168545,0.00007001244,1.190369e-7,0.002674825,0.00002941686,0.8975796,0.0002363386,0.00004035416,0.002549972],"study_design_scores_gemma":[0.001362029,0.0005508425,0.8231862,0.0001499959,0.00006389625,0.000003770442,0.001537918,0.0006746477,0.1719534,0.0003426168,0.00004568212,0.0001290124],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978532,0.0002055458,0.0001549322,0.001131606,0.00001935783,0.0005654228,0.00002233066,0.00001158912,0.00003607788],"genre_scores_gemma":[0.9979474,0.001418179,0.000251055,0.0001708224,0.00003321852,0.00007716792,0.00007958191,0.00002214895,4.453188e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7266437,"threshold_uncertainty_score":0.6807337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04902521530238122,"score_gpt":0.3056675614430028,"score_spread":0.2566423461406215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}