{"id":"W2172450144","doi":"10.1016/s0960-894x(03)00640-1","title":"Synthesis and evaluation of 4-Anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Aniline; Kinase; MAPK/ERK pathway; Phosphorylation; Mitogen-activated protein kinase; Structure–activity relationship; Stereochemistry; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006580611,0.0001811489,0.0002878211,0.00002885046,0.00004027705,0.000003310785,0.0001905268,0.0001628145,0.00006276427],"category_scores_gemma":[0.001362536,0.0001413387,0.0001146444,0.0001394194,0.0003192599,0.000003590161,0.00005722249,0.00009595566,3.565157e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002205036,"about_ca_system_score_gemma":0.0002525214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004297668,"about_ca_topic_score_gemma":0.000002384916,"domain_scores_codex":[0.9984751,0.0001424032,0.0004445833,0.00027899,0.0004824144,0.0001765281],"domain_scores_gemma":[0.9989472,0.00008294955,0.0003622039,0.0003641387,0.0001721969,0.0000712959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003743515,0.00004066268,0.00237313,0.0002056079,0.00007089543,0.000001365423,0.00007699319,0.00001077794,0.9966561,0.00001005993,0.000173496,0.0003434698],"study_design_scores_gemma":[0.0005716319,0.00005300295,0.000932208,0.0001792988,0.000267651,0.0000415645,0.0003358311,0.000009531804,0.9972923,0.0000260638,0.0001627293,0.0001281611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972448,0.001836731,0.00002014115,0.0001793527,0.0001331114,0.000178226,0.00002047706,0.000004202661,0.0003829026],"genre_scores_gemma":[0.9995393,0.00006185477,0.00006736389,0.00009156804,0.0001880801,0.00001071107,0.00001289513,0.0000180096,0.00001026528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294397,"threshold_uncertainty_score":0.5763625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333139077917522,"score_gpt":0.2330483175607817,"score_spread":0.2197169267816065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}